PDF(Pubmed)
Abstract：
BACKGROUND: Numerous studies indicate a potential protective role of helminths in diabetes mellitus (DM) progression. The complement system, vital for host defense, plays a crucial role in tissue homeostasis and immune surveillance. Dysregulated complement activation is implicated in diabetic complications. We aimed to investigate the influence of the helminth, Strongyloides stercoralis (Ss) on complement activation in individuals with type 2 DM (T2D).
METHODS: We assessed circulating levels of complement proteins (C1q, C2, C3, C4, C4b, C5, C5a, and MBL (Lectin)) and their regulatory components (Factor B, Factor D, Factor H, and Factor I) in individuals with T2D with (n = 60) or without concomitant Ss infection (n = 58). Additionally, we evaluated the impact of anthelmintic therapy on these parameters after 6 months in Ss-infected individuals (n = 60).
RESULTS: Ss+DM+ individuals demonstrated reduced levels of complement proteins (C1q, C4b, MBL (Lectin), C3, C5a, and C3b/iC3b) and complement regulatory proteins (Factor B and Factor D) compared to Ss-DM+ individuals. Following anthelmintic therapy, there was a partial reversal of these levels in Ss+DM+ individuals.
CONCLUSIONS: Our findings indicate that Ss infection reduces complement activation, potentially mitigating inflammatory processes in individuals with T2D. The study underscores the complex interplay between helminth infections, complement regulation, and diabetes mellitus, offering insights into potential therapeutic avenues.
METHODS: We assessed circulating levels of complement proteins (C1q, C2, C3, C4, C4b, C5, C5a, and MBL (Lectin)) and their regulatory components (Factor B, Factor D, Factor H, and Factor I) in individuals with T2D with (n = 60) or without concomitant Ss infection (n = 58). Additionally, we evaluated the impact of anthelmintic therapy on these parameters after 6 months in Ss-infected individuals (n = 60).
RESULTS: Ss+DM+ individuals demonstrated reduced levels of complement proteins (C1q, C4b, MBL (Lectin), C3, C5a, and C3b/iC3b) and complement regulatory proteins (Factor B and Factor D) compared to Ss-DM+ individuals. Following anthelmintic therapy, there was a partial reversal of these levels in Ss+DM+ individuals.
CONCLUSIONS: Our findings indicate that Ss infection reduces complement activation, potentially mitigating inflammatory processes in individuals with T2D. The study underscores the complex interplay between helminth infections, complement regulation, and diabetes mellitus, offering insights into potential therapeutic avenues.
摘要：
背景：许多研究表明蠕虫在糖尿病（DM）进展中具有潜在的保护作用。补充系统，对于宿主防御至关重要，在组织稳态和免疫监视中起着至关重要的作用。补体激活失调与糖尿病并发症有关。我们的目的是调查蠕虫的影响，2型DM（T2D）患者的补体激活。
方法：我们评估了补体蛋白的循环水平（C1q，C2,C3,C4,C4b,C5、C5a、和MBL(凝集素)及其调节成分(因子B，系数D,系数H,和因子I）在患有T2D并伴有（n=60）或不伴有Ss感染（n=58）的个体中。此外,我们评估了Ss感染个体6个月后驱虫治疗对这些参数的影响(n=60).
结果：Ss+DM+个体显示补体蛋白水平降低（C1q，C4b,MBL（凝集素），C3,C5a,和C3b/iC3b）和补体调节蛋白（因子B和因子D）与Ss-DM+个体相比。驱虫治疗后,Ss+DM+个体的这些水平有部分逆转。
结论：我们的发现表明Ss感染降低了补体激活，可能减轻T2D患者的炎症过程。这项研究强调了蠕虫感染之间复杂的相互作用，补体调节，和糖尿病，提供潜在治疗途径的见解。
方法：我们评估了补体蛋白的循环水平（C1q，C2,C3,C4,C4b,C5、C5a、和MBL(凝集素)及其调节成分(因子B，系数D,系数H,和因子I）在患有T2D并伴有（n=60）或不伴有Ss感染（n=58）的个体中。此外,我们评估了Ss感染个体6个月后驱虫治疗对这些参数的影响(n=60).
结果：Ss+DM+个体显示补体蛋白水平降低（C1q，C4b,MBL（凝集素），C3,C5a,和C3b/iC3b）和补体调节蛋白（因子B和因子D）与Ss-DM+个体相比。驱虫治疗后,Ss+DM+个体的这些水平有部分逆转。
结论：我们的发现表明Ss感染降低了补体激活，可能减轻T2D患者的炎症过程。这项研究强调了蠕虫感染之间复杂的相互作用，补体调节，和糖尿病，提供潜在治疗途径的见解。
