Abstract：
Purpose: To determine whether high-sensitivity C-reactive protein (hsCRP) is associated with incident Metabolic Syndrome (MetS) among U.S. Hispanic/Latino adults. Patients and Methods: The Hispanic Community Health Study/Study of Latinos is a longitudinal observational cohort assessing cardiovascular health among diverse U.S. Hispanic/Latino adults. hsCRP was measured at visit 1 (2008-2011) and classified as low, moderate, or high, based on the Centers for Disease Control and Prevention and American Heart Association (CDC/AHA) guidelines. All MetS components [abdominal obesity, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, and fasting glucose] were measured at visit 1 and visit 2 (2014-2017). MetS was defined as the presence of three or more components based on the 2005 definition from the modified Third Report of the National Cholesterol Education Program Adult Treatment Panel (modified NCEP ATP III). Participants free of MetS at visit 1 and with complete data on hsCRP and all MetS components were included (n = 6121 participants). We used Poisson regression analysis to determine whether hsCRP was associated with incident MetS after adjusting for demographic, behavioral, and clinical factors. All analyses accounted for the complex survey design of the study. Results: In fully adjusted models, moderate versus low hsCRP was associated with a 33% increased risk of MetS [incidence rate ratio (IRR): 1.33, 95% confidence interval (CI): 1.10-1.61], while high versus low hsCRP was associated with a 89% increased risk of MetS (IRR: 1.89, 95% CI: 1.58-2.25). Conclusions: Greater levels of hsCRP were associated with new onset of MetS in a diverse sample of U.S. Hispanic/Latino adults. Results suggest that hsCRP may be an independent risk factor for MetS.
摘要：
目的：确定高敏C反应蛋白（hsCRP）是否与美国西班牙裔/拉丁裔成年人的代谢综合征（MetS）相关。患者和方法：西班牙裔社区健康研究/拉丁裔研究是一个纵向观察队列，评估美国不同西班牙裔/拉丁裔成年人的心血管健康。hsCRP在第1次(2008-2011年)测量，并分类为低，中度,或高，根据疾病控制和预防中心和美国心脏协会（CDC/AHA）指南。所有MetS成分[腹部肥胖，甘油三酯，高密度脂蛋白（HDL）胆固醇，血压,和空腹血糖]在第1次和第2次(2014-2017年)测量。根据2005年国家胆固醇教育计划成人治疗小组修改后的第三次报告（修改后的NCEPATPIII）的定义，将MetS定义为存在三种或更多种成分。纳入第1次就诊时无MetS且具有hsCRP和所有MetS组分完整数据的参与者(n=6121名参与者)。我们使用泊松回归分析来确定hsCRP是否与人口统计校正后的事件MetS相关。行为，和临床因素。所有分析都说明了研究的复杂调查设计。结果：在完全调整的模型中，中、低hsCRP与33%的MetS风险增加相关[发生率比(IRR):1.33,95%置信区间(CI):1.10-1.61],而高与低hsCRP与代谢综合征风险增加89%相关(IRR:1.89,95%CI:1.58-2.25).结论：在不同的美国西班牙裔/拉丁裔成年人样本中，较高的hsCRP水平与MetS的新发相关。结果提示hsCRP可能是MetS的独立危险因素。
