Abstract：
Necrotizing infundibular crystalline folliculitis (NICF) is a rare type of necrotizing folliculitis. The disease typically manifests as folliculocentric papules arising in a seborrheic distribution. Only 23 cases exist in the literature. Most reported cases have arisen spontaneously, but a small number of drug-induced cases in the setting of epidermal-derived growth factor, vascular endothelial-derived growth factor, or PD-1 inhibitor therapy have been reported. Colonization by bacteria and/or yeast occurs frequently. The etiology remains unknown, but some suggest a complex interplay with an aberrant microbiome, sebaceous gland dysfunction, and perturbed EGFR signaling in follicular infundibula. Histopathologic findings include rupture of follicular epithelium, neutrophilic inflammation, and nodular cup-shaped crystal deposits. We present a case of spontaneous, recurrent NICF in an inverse pattern in the inguinal region.
摘要：
坏死性漏斗状结晶毛囊炎（NICF）是一种罕见的坏死性毛囊炎。该疾病通常表现为以卵泡为中心的丘疹，出现在脂溢性分布中。文献中只有23例。大多数报告病例是自发出现的，但是在表皮衍生生长因子的背景下，少数药物诱导的病例，血管内皮衍生生长因子，或PD-1抑制剂治疗已被报道。细菌和/或酵母的定殖频繁发生。病因尚不清楚,但是有些人提出了与异常微生物组的复杂相互作用，皮脂腺功能障碍,并扰乱了卵泡漏斗中的EGFR信号传导。组织病理学发现包括滤泡上皮破裂，嗜中性炎症，和结节状的杯状晶体沉积物。我们提出了一个自发的案例，腹股沟区呈反向模式的复发性NICF。
