PDF(Pubmed)
Abstract：
UNASSIGNED: Colorectal cancer (CRC) is one of the most common cancers worldwide and is related to diet and obesity. Currently, crosstalk between lipid metabolism and CRC has been reported; however, the specific mechanism is not yet understood. In this study, we screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue. According to the results of the biological analysis, we speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery.
UNASSIGNED: We screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue.
UNASSIGNED: We speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery.
UNASSIGNED: In this study, the findings raise the possibility of crosstalk between lipid metabolism and CRC through the exosomal delivery of lncRNAs.
UNASSIGNED: We screened differentially expressed long non-coding RNAs (lncRNAs) and mRNAs from primary cancer, paracancer, and white adipose tissue of CRC patients. We screened and analyzed the genes differentially expressed between primary and paracancer tissue and between paracancer and white adipose tissue but not between primary and white adipose tissue.
UNASSIGNED: We speculated a lncRNA (MIR503HG) that may be involved in the crosstalk between CRC and lipid metabolism through exosome delivery.
UNASSIGNED: In this study, the findings raise the possibility of crosstalk between lipid metabolism and CRC through the exosomal delivery of lncRNAs.
摘要：
结直肠癌（CRC）是全球最常见的癌症之一，与饮食和肥胖有关。目前,已经报道了脂质代谢与CRC之间的串扰；然而，具体机制尚不清楚。在这项研究中,我们从原发癌中筛选了差异表达的长链非编码RNA（lncRNA）和mRNA，副癌者,CRC患者的白色脂肪组织。我们筛选并分析了在原发性和癌旁组织之间以及在癌旁组织和白色脂肪组织之间差异表达的基因，但在原发性和白色脂肪组织之间不差异表达的基因。根据生物分析的结果,我们推测lncRNA(MIR503HG)可能通过外泌体递送参与CRC和脂质代谢之间的串扰。
■我们从原发癌中筛选了差异表达的长链非编码RNA（lncRNA）和mRNA，副癌者,CRC患者的白色脂肪组织。我们筛选并分析了在原发性和癌旁组织之间以及在癌旁组织和白色脂肪组织之间差异表达的基因，但在原发性和白色脂肪组织之间不差异表达的基因。
■我们推测了一种lncRNA（MIR503HG），该lncRNA可能通过外泌体递送参与CRC与脂质代谢之间的串扰。
■在这项研究中，该研究结果通过lncRNAs的外泌体传递提高了脂质代谢和CRC之间串扰的可能性。
■我们从原发癌中筛选了差异表达的长链非编码RNA（lncRNA）和mRNA，副癌者,CRC患者的白色脂肪组织。我们筛选并分析了在原发性和癌旁组织之间以及在癌旁组织和白色脂肪组织之间差异表达的基因，但在原发性和白色脂肪组织之间不差异表达的基因。
■我们推测了一种lncRNA（MIR503HG），该lncRNA可能通过外泌体递送参与CRC与脂质代谢之间的串扰。
■在这项研究中，该研究结果通过lncRNAs的外泌体传递提高了脂质代谢和CRC之间串扰的可能性。
