PDF(Pubmed)
Abstract：
Sodium-glucose cotransporters (SGLT) and glucose transporters (GLUT) have been shown to influence diabetes management by modulating glucose uptake by the intestine. Therefore, alterations in gastrointestinal anatomy during bariatric surgery can change SGLT and GLUT receptor activity. These changes offer an additional mechanism for weight loss and may explain the differential impact of the various bariatric surgical procedures. This review examines the current literature on SGLT and GLUT receptors and their effects on weight loss through genetic studies, pharmacologic inhibition, and how SGLT/GLUT receptors impact surgical physiologic modulation. A better understanding of Type I sodium-glucose cotransport receptors (SGLT-1), GLUT-2, and GLUT-5 could provide insight for improved procedures and allow us to determine the best method to tailor operations to a patient\'s individual needs.
摘要：
已显示钠-葡萄糖协同转运蛋白(SGLT)和葡萄糖转运蛋白(GLUT)通过调节肠道的葡萄糖摄取来影响糖尿病管理。因此,减肥手术期间胃肠道解剖结构的改变可以改变SGLT和GLUT受体的活性。这些变化为减肥提供了额外的机制，并可以解释各种减肥手术的不同影响。这篇综述通过基因研究来审查SGLT和GLUT受体及其对体重减轻的影响的最新文献。药理抑制，以及SGLT/GLUT受体如何影响手术生理调制。更好地理解I型钠-葡萄糖共转运受体（SGLT-1），GLUT-2和GLUT-5可以为改进的程序提供见解，并使我们能够确定根据患者的个人需求定制手术的最佳方法。
