PDF(Pubmed)
Abstract：
UNASSIGNED: Adolescents with disrupted rest-activity rhythms (RAR) including shorter sleep duration, later sleep timing and low physical activity levels have higher risk for mental and behavioral problems. However, it remains unclear whether the same associations can be observed for within-subject changes in RAR.
UNASSIGNED: Our longitudinal investigation on RAR used Fitbit data from the Adolescent Brain Cognitive Development (ABCD) Study at the 2-year (FL2: aged 10-13 years) and 4-year follow-up (FL4: aged 13-16 years). 963 youths had good-quality Fitbit data at both time points. In this study we examined changes in RAR from FL2 to FL4, their environmental and demographic contributors as well as brain and behavioral correlates.
UNASSIGNED: From FL2 to FL4, adolescents showed decreases in sleep duration and physical activity as well as delayed sleep timing (Cohen\'s d .44-.75). The contributions of environmental and demographic factors to RAR changes were greatest to sleep timing (explained 10% variance) and least to sleep duration (explained 1% variance). Delays in sleep timing had stronger correlations with behavioral problems including greater impulsivity and poor academic performance than reductions in sleep duration or physical activity. Additionally, the various brain measures differed in their sensitivity to RAR changes. Reductions in sleep duration were associated with decreased brain functional connectivity between subcortical regions and sensorimotor and cingulo-opercular networks and with enhanced functional connectivity between sensorimotor, visual and auditory networks. Delays in sleep timing were mainly associated with grey matter changes in subcortical regions.
UNASSIGNED: The current findings corroborate the role of sleep and physical activity in adolescent\'s brain neurodevelopment and behavior problems. RAR might serve as biomarkers for monitoring behavioral problems in adolescents and to serve as potential therapeutic targets for mental disorders.
UNASSIGNED: Our longitudinal investigation on RAR used Fitbit data from the Adolescent Brain Cognitive Development (ABCD) Study at the 2-year (FL2: aged 10-13 years) and 4-year follow-up (FL4: aged 13-16 years). 963 youths had good-quality Fitbit data at both time points. In this study we examined changes in RAR from FL2 to FL4, their environmental and demographic contributors as well as brain and behavioral correlates.
UNASSIGNED: From FL2 to FL4, adolescents showed decreases in sleep duration and physical activity as well as delayed sleep timing (Cohen\'s d .44-.75). The contributions of environmental and demographic factors to RAR changes were greatest to sleep timing (explained 10% variance) and least to sleep duration (explained 1% variance). Delays in sleep timing had stronger correlations with behavioral problems including greater impulsivity and poor academic performance than reductions in sleep duration or physical activity. Additionally, the various brain measures differed in their sensitivity to RAR changes. Reductions in sleep duration were associated with decreased brain functional connectivity between subcortical regions and sensorimotor and cingulo-opercular networks and with enhanced functional connectivity between sensorimotor, visual and auditory networks. Delays in sleep timing were mainly associated with grey matter changes in subcortical regions.
UNASSIGNED: The current findings corroborate the role of sleep and physical activity in adolescent\'s brain neurodevelopment and behavior problems. RAR might serve as biomarkers for monitoring behavioral problems in adolescents and to serve as potential therapeutic targets for mental disorders.
摘要：
■休息活动节律（RAR）中断的青少年，包括较短的睡眠时间，晚睡时间和低体力活动水平有较高的精神和行为问题的风险。然而,尚不清楚RAR的受试者内部变化是否可以观察到相同的关联.
■我们对RAR的纵向调查使用了2年（FL2：年龄10-13岁）和4年随访（FL4：年龄13-16岁）的青少年脑认知发育（ABCD）研究的Fitbit数据。963名年轻人在两个时间点都有高质量的Fitbit数据。在这项研究中，我们研究了从FL2到FL4的RAR变化，它们的环境和人口统计学因素以及大脑和行为相关因素。
■从FL2到FL4，青少年的睡眠时间和身体活动减少，睡眠时间延迟（Cohen'sd.44-.75）。环境和人口统计学因素对RAR变化的贡献对睡眠时间的影响最大（解释为10％方差），对睡眠持续时间的影响最小（解释为1％方差）。与睡眠持续时间或身体活动的减少相比，睡眠时间的延迟与行为问题的相关性更强，包括更大的冲动性和学习成绩差。此外,各种大脑测量对RAR变化的敏感性不同。睡眠持续时间的减少与皮质下区域和感觉运动和扣带-手术网络之间的功能连接降低以及感觉运动之间的功能连接增强有关。视觉和听觉网络。睡眠时间的延迟主要与皮质下区域的灰质变化有关，而体力活动水平的降低主要与白质纤维束的完整性降低有关。
■目前的发现证实了睡眠和身体活动在青少年脑神经发育和行为问题中的作用。RAR可能作为监测或治疗青少年精神和行为问题的生物标志物或治疗目标。
■我们对RAR的纵向调查使用了2年（FL2：年龄10-13岁）和4年随访（FL4：年龄13-16岁）的青少年脑认知发育（ABCD）研究的Fitbit数据。963名年轻人在两个时间点都有高质量的Fitbit数据。在这项研究中，我们研究了从FL2到FL4的RAR变化，它们的环境和人口统计学因素以及大脑和行为相关因素。
■从FL2到FL4，青少年的睡眠时间和身体活动减少，睡眠时间延迟（Cohen'sd.44-.75）。环境和人口统计学因素对RAR变化的贡献对睡眠时间的影响最大（解释为10％方差），对睡眠持续时间的影响最小（解释为1％方差）。与睡眠持续时间或身体活动的减少相比，睡眠时间的延迟与行为问题的相关性更强，包括更大的冲动性和学习成绩差。此外,各种大脑测量对RAR变化的敏感性不同。睡眠持续时间的减少与皮质下区域和感觉运动和扣带-手术网络之间的功能连接降低以及感觉运动之间的功能连接增强有关。视觉和听觉网络。睡眠时间的延迟主要与皮质下区域的灰质变化有关，而体力活动水平的降低主要与白质纤维束的完整性降低有关。
■目前的发现证实了睡眠和身体活动在青少年脑神经发育和行为问题中的作用。RAR可能作为监测或治疗青少年精神和行为问题的生物标志物或治疗目标。
