PDF(Pubmed)
Abstract：
During the coronavirus disease 2019 (COVID-19) pandemic, a subset of individuals continues to suffer from symptoms including fatigue, post-exertional malaise, dyspnea, bone loss, and memory and neurocognitive dysfunction for months and even years after infection. This clinical phenomenon has been labeled \'Long-haul COVID\' or \'post-acute sequelae of COVID-19 (PASC)\'; however, the underlying pathophysiological mechanisms remain unclear. In a recent study published in Cell, Wong et al. revealed that viral infection and type I interferon-driven reduction of peripheral serotonin impaired hippocampal responses and short-term memory through vagal neurons in patients with PASC. Therefore, the study provided novel insights into how serotonin links persistent viral inflammation with the neurocognitive symptoms of Long-haul COVID and actionable therapeutic targets for patients with PASC.
摘要：
在2019年冠状病毒病（COVID-19）大流行期间，一部分人继续患有包括疲劳在内的症状，劳累后不适,呼吸困难,骨丢失,感染后数月甚至数年的记忆和神经认知功能障碍。这种临床现象被标记为“长途COVID”或“COVID-19急性后遗症（PASC）”；然而，潜在的病理生理机制尚不清楚.在最近发表在《细胞》上的一项研究中，Wong等人。揭示病毒感染和I型干扰素驱动的外周5-羟色胺减少损害了PASC患者通过迷走神经元的海马反应和短期记忆。因此,该研究提供了新的见解，揭示了5-羟色胺如何将持续性病毒性炎症与远程COVID的神经认知症状联系起来，以及PASC患者的可行治疗目标。
