Abstract：
Obesity and its associated complications pose a significant burden on health. The non-shivering thermogenesis (NST) and metabolic capacity properties of brown adipose tissue (BAT), which are distinct from those of white adipose tissue (WAT), in combating obesity and its related metabolic diseases has been well documented. However, beige adipose tissue, the third and relatively novel type of adipose tissue, which emerges in extensive presence of WAT and shares similar favorable metabolic properties with BAT, has garnered considerable attention in recent years. In this review, we focused on the role of G protein-coupled receptors (GPCRs), the largest receptor family and the most successful class of drug targets in humans, in the induction of beige adipocytes. More importantly, we highlight researchers\' clinical treatment attempts to ameliorate obesity and other related metabolic diseases through the formation and activation of beige adipose tissue. In summary, this review provides valuable insights into the formation of beige adipose tissue and the involvement of GPCRs, based on the latest advancements in scientific research.
摘要：
肥胖及其相关并发症对健康构成重大负担。棕色脂肪组织（BAT）的非发抖产热（NST）和代谢能力特性，与白色脂肪组织(WAT)不同，在对抗肥胖及其相关的代谢性疾病方面已有大量文献记载。然而,米色脂肪组织,第三种也是相对新颖的脂肪组织，在WAT的广泛存在下出现，并与BAT共享类似的有利代谢特性，近年来引起了相当多的关注。在这次审查中,我们专注于G蛋白偶联受体（GPCRs）的作用，人类最大的受体家族和最成功的药物靶标，在米色脂肪细胞的诱导中。更重要的是,我们强调研究人员的临床治疗尝试通过米色脂肪组织的形成和激活来改善肥胖和其他相关代谢性疾病。总之,这篇综述为米色脂肪组织的形成和GPCRs的参与提供了有价值的见解，基于科学研究的最新进展。
