Abstract：
OBJECTIVE: To describe serum irisin and fibroblast growth factor-21 (FGF-21) concentrations in healthy female adolescents with different training activity patterns and their associations with bone mineral properties and metabolic markers.
METHODS: A total of 62 adolescent girls aged 14-18 years were recruited: 22 rhythmic gymnasts, 20 swimmers, and 20 untrained controls. Bone mineral characteristics by dual-energy X-ray absorptiometry, daily energy intake by dietary recall, serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen were measured in all girls.
RESULTS: Whole body and lumbar spine areal bone mineral density and lumbar spine bone mineral content were higher in the rhythmic gymnasts group compared with swimmers and untrained controls groups (P < .05). Serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen levels were not significantly different between the groups. In the rhythmic gymnasts group, serum FGF-21 concentration was positively correlated with lumbar spine areal bone mineral density independently of confounding factors (r = .51; P = .027).
CONCLUSIONS: Serum irisin and FGF-21 levels were not different between adolescent eumenorrheic girls with different training activity patterns. FGF-21 was positively associated with lumbar spine areal bone mineral density, which predominantly consists of trabecular bone in adolescent rhythmic gymnasts.
METHODS: A total of 62 adolescent girls aged 14-18 years were recruited: 22 rhythmic gymnasts, 20 swimmers, and 20 untrained controls. Bone mineral characteristics by dual-energy X-ray absorptiometry, daily energy intake by dietary recall, serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen were measured in all girls.
RESULTS: Whole body and lumbar spine areal bone mineral density and lumbar spine bone mineral content were higher in the rhythmic gymnasts group compared with swimmers and untrained controls groups (P < .05). Serum irisin, FGF-21, undercarboxylated osteocalcin, and C-terminal telopeptide of type I collagen levels were not significantly different between the groups. In the rhythmic gymnasts group, serum FGF-21 concentration was positively correlated with lumbar spine areal bone mineral density independently of confounding factors (r = .51; P = .027).
CONCLUSIONS: Serum irisin and FGF-21 levels were not different between adolescent eumenorrheic girls with different training activity patterns. FGF-21 was positively associated with lumbar spine areal bone mineral density, which predominantly consists of trabecular bone in adolescent rhythmic gymnasts.
摘要：
目的：描述具有不同训练活动模式的健康女性青少年的血清irisin和成纤维细胞生长因子-21（FGF-21）浓度及其与骨矿物质特性和代谢标志物的关系。
方法：共招募了62名年龄在14-18岁之间的少女：22名艺术体操运动员，20名游泳者,和20个未经训练的控制。通过双能X射线吸收法测量骨矿物质特征，通过饮食召回每日能量摄入，血清irisin,FGF-21，低羧化骨钙蛋白，在所有女孩中测量I型胶原蛋白的C末端端肽。
结果：与游泳运动员和未经训练的对照组相比，有节奏体操运动员组的全身和腰椎区域骨密度和腰椎骨矿物质含量更高（P<0.05）。血清irisin,FGF-21，低羧化骨钙蛋白，I型胶原蛋白的C末端端肽水平在两组之间没有显着差异。在艺术体操运动员组中，血清FGF-21浓度与腰椎区域骨密度呈正相关，独立于混杂因素（r=.51；P=.027）。
结论：不同训练活动模式的青春期闭经女孩血清irisin和FGF-21水平无差异。FGF-21与腰椎区域骨密度呈正相关,青少年艺术体操运动员主要由小梁骨组成。
方法：共招募了62名年龄在14-18岁之间的少女：22名艺术体操运动员，20名游泳者,和20个未经训练的控制。通过双能X射线吸收法测量骨矿物质特征，通过饮食召回每日能量摄入，血清irisin,FGF-21，低羧化骨钙蛋白，在所有女孩中测量I型胶原蛋白的C末端端肽。
结果：与游泳运动员和未经训练的对照组相比，有节奏体操运动员组的全身和腰椎区域骨密度和腰椎骨矿物质含量更高（P<0.05）。血清irisin,FGF-21，低羧化骨钙蛋白，I型胶原蛋白的C末端端肽水平在两组之间没有显着差异。在艺术体操运动员组中，血清FGF-21浓度与腰椎区域骨密度呈正相关，独立于混杂因素（r=.51；P=.027）。
结论：不同训练活动模式的青春期闭经女孩血清irisin和FGF-21水平无差异。FGF-21与腰椎区域骨密度呈正相关,青少年艺术体操运动员主要由小梁骨组成。
