PDF(Pubmed)
Abstract：
Cancer occurrence and development are closely related to increased lipid production and glucose consumption. Lipids are the basic component of the cell membrane and play a significant role in cancer cell processes such as cell-to-cell recognition, signal transduction, and energy supply, which are vital for cancer cell rapid proliferation, invasion, and metastasis. Sterol regulatory element-binding transcription factor 1 (SREBP1) is a key transcription factor regulating the expression of genes related to cholesterol biosynthesis, lipid homeostasis, and fatty acid synthesis. In addition, SREBP1 and its upstream or downstream target genes are implicated in various metabolic diseases, particularly cancer. However, no review of SREBP1 in cancer biology has yet been published. Herein, we summarized the roles and mechanisms of SREBP1 biological processes in cancer cells, including SREBP1 modification, lipid metabolism and reprogramming, glucose and mitochondrial metabolism, immunity, and tumor microenvironment, epithelial-mesenchymal transition, cell cycle, apoptosis, and ferroptosis. Additionally, we discussed the potential role of SREBP1 in cancer prognosis, drug response such as drug sensitivity to chemotherapy and radiotherapy, and the potential drugs targeting SREBP1 and its corresponding pathway, elucidating the potential clinical application based on SREBP1 and its corresponding signal pathway.
摘要：
癌症的发生和发展与脂质产生和葡萄糖消耗的增加密切相关。脂质是细胞膜的基本组成部分，在细胞间识别等癌细胞过程中起着重要作用，信号转导，和能源供应，这对癌细胞的快速增殖至关重要，入侵,和转移。甾醇调节元件结合转录因子1(SREBP1)是调节胆固醇生物合成相关基因表达的关键转录因子,脂质稳态，和脂肪酸合成。此外,SREBP1及其上游或下游靶基因与各种代谢疾病有关。尤其是癌症。然而,尚未发表SREBP1在癌症生物学中的评论。在这里，我们总结了SREBP1生物学过程在癌细胞中的作用和机制，包括SREBP1修改，脂质代谢和重编程，葡萄糖和线粒体代谢，豁免权,和肿瘤微环境，上皮-间质转化，细胞周期,凋亡，和铁中毒。此外,我们讨论了SREBP1在癌症预后中的潜在作用，药物反应，如对化疗和放疗的药物敏感性，以及针对SREBP1及其相应通路的潜在药物，阐明了基于SREBP1及其相应信号通路的潜在临床应用。
