PDF(Pubmed)
Abstract：
UNASSIGNED: Metabolic dysfunction-associated fatty liver disease (MAFLD) is presently the most prevalent chronic liver disorder globally that is closely linked to obesity, dyslipidemia metabolic syndrome, and type 2 diabetes mellitus (T2DM). Its pathogenesis is strongly associated with inflammation, and diet is a major factor in reducing inflammation. However, current research has focused primarily on exploring the relationship between diet and NAFLD, with less research on its link to MAFLD.
UNASSIGNED: In this research, using dietary inflammatory index (DII) as a measure to assess dietary quality, we analyzed the relationship between diet and MAFLD. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018, including 3,633 adults with complete DII and MAFLD, were used to develop cross-sectional analyses. Logistic regression analysis was adapted for investigating the relationship between DII and MAFLD development. Additionally, subgroup analysis and threshold effect analysis were carried out.
UNASSIGNED: A positive link between DII and MAFLD was found in the fully adjusted model (OR = 1.05; 95%CI, 1.00-1.11, p < 0.05). Subgroup analysis indicated that there was no significant dependence for the connection between DII and MAFLD except for the subgroup stratified by age. Compared with other age groups, people with MAFLD had 20% higher DII scores than non-MAFLD participants in those aged 20-41 years old (OR = 1.20; 95%CI, 1.08-1.33, p < 0.001). Furthermore, we found a U-shaped curve with an inflection point of 3.06 illustrating the non-linear connection between DII and MAFLD.
UNASSIGNED: As a result, our research indicates that pro-inflammatory diet may increase the chance of MAFLD development, thus improved dietary patterns as a lifestyle intervention is an important strategy to decrease the incidence of MAFLD.
UNASSIGNED: In this research, using dietary inflammatory index (DII) as a measure to assess dietary quality, we analyzed the relationship between diet and MAFLD. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018, including 3,633 adults with complete DII and MAFLD, were used to develop cross-sectional analyses. Logistic regression analysis was adapted for investigating the relationship between DII and MAFLD development. Additionally, subgroup analysis and threshold effect analysis were carried out.
UNASSIGNED: A positive link between DII and MAFLD was found in the fully adjusted model (OR = 1.05; 95%CI, 1.00-1.11, p < 0.05). Subgroup analysis indicated that there was no significant dependence for the connection between DII and MAFLD except for the subgroup stratified by age. Compared with other age groups, people with MAFLD had 20% higher DII scores than non-MAFLD participants in those aged 20-41 years old (OR = 1.20; 95%CI, 1.08-1.33, p < 0.001). Furthermore, we found a U-shaped curve with an inflection point of 3.06 illustrating the non-linear connection between DII and MAFLD.
UNASSIGNED: As a result, our research indicates that pro-inflammatory diet may increase the chance of MAFLD development, thus improved dietary patterns as a lifestyle intervention is an important strategy to decrease the incidence of MAFLD.
摘要：
■代谢功能障碍相关的脂肪性肝病（MAFLD）是目前全球最普遍的慢性肝病，与肥胖密切相关。血脂异常代谢综合征,2型糖尿病（T2DM）。其发病机制与炎症密切相关，饮食是减少炎症的主要因素。然而,目前的研究主要集中在探索饮食与NAFLD之间的关系，对其与MAFLD联系的研究较少。
■在这项研究中，使用膳食炎症指数（DII）作为评估膳食质量的指标，我们分析了饮食与MAFLD之间的关系。来自2017-2018年国家健康和营养检查调查（NHANES）的数据，包括3,633名完全DII和MAFLD的成年人。用于开发横截面分析。采用Logistic回归分析探讨DII与MAFLD发生的关系。此外,进行亚组分析和阈值效应分析。
■在完全调整的模型中发现了DII和MAFLD之间的正联系（OR=1.05；95CI，1.00-1.11，p<0.05）。亚组分析表明，除了按年龄分层的亚组外，DII和MAFLD之间的联系没有显着依赖性。与其他年龄组相比，在20~41岁的人群中,MAFLD患者的DII评分比非MAFLD患者高20%(OR=1.20;95CI,1.08~1.33,p<0.001).此外，我们发现了一个拐点为3.06的U形曲线,说明了DII和MAFLD之间的非线性联系.
■因此，我们的研究表明，促炎饮食可能会增加MAFLD发展的机会，因此,改善膳食模式作为生活方式干预是降低MAFLD发病率的重要策略.
■在这项研究中，使用膳食炎症指数（DII）作为评估膳食质量的指标，我们分析了饮食与MAFLD之间的关系。来自2017-2018年国家健康和营养检查调查（NHANES）的数据，包括3,633名完全DII和MAFLD的成年人。用于开发横截面分析。采用Logistic回归分析探讨DII与MAFLD发生的关系。此外,进行亚组分析和阈值效应分析。
■在完全调整的模型中发现了DII和MAFLD之间的正联系（OR=1.05；95CI，1.00-1.11，p<0.05）。亚组分析表明，除了按年龄分层的亚组外，DII和MAFLD之间的联系没有显着依赖性。与其他年龄组相比，在20~41岁的人群中,MAFLD患者的DII评分比非MAFLD患者高20%(OR=1.20;95CI,1.08~1.33,p<0.001).此外，我们发现了一个拐点为3.06的U形曲线,说明了DII和MAFLD之间的非线性联系.
■因此，我们的研究表明，促炎饮食可能会增加MAFLD发展的机会，因此,改善膳食模式作为生活方式干预是降低MAFLD发病率的重要策略.
