UNASSIGNED: Four groups of male Albino rats were given their respective treatment orally for 60 days in a dose of 1/20 of the LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 mg/Kg b.wt/day), IONs (200 mg/kg b.wt/day) and Al2O3NPs (100 mg/Kg b.wt/day) and a fifth group served as a control group.
UNASSIGNED: The mRNA level of CYP 1A1 and NBN showed up-regulation in all the NPs-treated groups relative to the control group. ZnONPs group recorded the highest expression level while the TiO2NPs group showed the lowest expression level transcript. Conclusion:The toxic effects produced by these nanoparticles were more pronounced in the case of zinc oxide, followed by aluminum oxide, iron oxide nanoparticles and titanium dioxide, respectively.
■四组雄性白化病大鼠分别口服治疗60天,剂量为1/20的LD50TiO2NPs(600mg/Kgb.wt/天),ZnONPs(340mg/Kgb.wt/天),ION(200mg/kgb.wt/天)和Al2O3NP(100mg/kgb.wt/天),第五组作为对照组。
■CYP1A1和NBN的mRNA水平在所有NP处理组中相对于对照组显示出上调。ZnONPs组记录的表达水平最高,而TiO2NP组显示的表达水平最低。结论:在氧化锌的情况下,这些纳米颗粒产生的毒性作用更为明显,其次是氧化铝,纳米氧化铁和二氧化钛,分别。