PDF(Pubmed)
Abstract：
UNASSIGNED: Metal oxide nanoparticles are currently used widely in many aspects of human and animal life with broad prospects for biomedical purposes. The present work was carried out to investigate the effects of orally administrated TiO2NPs, ZnONPs, IONs and Al2O3NPs on the mRNA expression level of CYP 1A1 and NBN in the rat liver.
UNASSIGNED: Four groups of male Albino rats were given their respective treatment orally for 60 days in a dose of 1/20 of the LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 mg/Kg b.wt/day), IONs (200 mg/kg b.wt/day) and Al2O3NPs (100 mg/Kg b.wt/day) and a fifth group served as a control group.
UNASSIGNED: The mRNA level of CYP 1A1 and NBN showed up-regulation in all the NPs-treated groups relative to the control group. ZnONPs group recorded the highest expression level while the TiO2NPs group showed the lowest expression level transcript. Conclusion:The toxic effects produced by these nanoparticles were more pronounced in the case of zinc oxide, followed by aluminum oxide, iron oxide nanoparticles and titanium dioxide, respectively.
UNASSIGNED: Four groups of male Albino rats were given their respective treatment orally for 60 days in a dose of 1/20 of the LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 mg/Kg b.wt/day), IONs (200 mg/kg b.wt/day) and Al2O3NPs (100 mg/Kg b.wt/day) and a fifth group served as a control group.
UNASSIGNED: The mRNA level of CYP 1A1 and NBN showed up-regulation in all the NPs-treated groups relative to the control group. ZnONPs group recorded the highest expression level while the TiO2NPs group showed the lowest expression level transcript. Conclusion:The toxic effects produced by these nanoparticles were more pronounced in the case of zinc oxide, followed by aluminum oxide, iron oxide nanoparticles and titanium dioxide, respectively.
摘要：
■金属氧化物纳米颗粒目前广泛用于人类和动物生活的许多方面，具有广阔的生物医学前景。目前的工作是研究口服TiO2NP的效果，ZnONPs,IONs和Al2O3NPs对年夜鼠肝脏CYP一1A1和NBNmRNA表达程度的影响。
■四组雄性白化病大鼠分别口服治疗60天，剂量为1/20的LD50TiO2NPs（600mg/Kgb.wt/天），ZnONPs（340mg/Kgb.wt/天），ION（200mg/kgb.wt/天）和Al2O3NP（100mg/kgb.wt/天），第五组作为对照组。
■CYP1A1和NBN的mRNA水平在所有NP处理组中相对于对照组显示出上调。ZnONPs组记录的表达水平最高,而TiO2NP组显示的表达水平最低。结论：在氧化锌的情况下，这些纳米颗粒产生的毒性作用更为明显，其次是氧化铝，纳米氧化铁和二氧化钛,分别。
■四组雄性白化病大鼠分别口服治疗60天，剂量为1/20的LD50TiO2NPs（600mg/Kgb.wt/天），ZnONPs（340mg/Kgb.wt/天），ION（200mg/kgb.wt/天）和Al2O3NP（100mg/kgb.wt/天），第五组作为对照组。
■CYP1A1和NBN的mRNA水平在所有NP处理组中相对于对照组显示出上调。ZnONPs组记录的表达水平最高,而TiO2NP组显示的表达水平最低。结论：在氧化锌的情况下，这些纳米颗粒产生的毒性作用更为明显，其次是氧化铝，纳米氧化铁和二氧化钛,分别。
