PDF(Pubmed)
Abstract：
UNASSIGNED: Observational studies have reported that Helicobacter pylori (H. pylori) infection is associated with a series of pregnancy and neonatal outcomes. However, the results have been inconsistent, and the causal effect is unknown.
UNASSIGNED: A two-sample Mendelian randomization (MR) study was performed using summary-level statistics for anti-H. pylori IgG levels from the Avon Longitudinal Study of Parents and Children Cohort. Outcome data for pregnancy (miscarriage, preeclampsia-eclampsia, gestational diabetes mellitus, placental abruption, premature rupture of membranes, postpartum hemorrhage) and neonates (birthweight, gestational age, and preterm birth) were sourced from genome-wide association meta-analysis as well as the FinnGen and Early Growth Genetics Consortium. Causal estimates were calculated by five methods including inverse variance weighted (IVW). The heterogeneity of instrumental variables was quantified by Cochran\'s Q test, while sensitivity analyses were performed via MR-Egger, MR-PRESSO, and leave-one-out tests.
UNASSIGNED: IVW estimates suggested that genetically predicted anti-H. pylori IgG levels were significantly associated with increased risks of preeclampsia-eclampsia (odds ratio [OR] = 1.12, 95% confidence interval [CI] 1.01-1.24, P = 0.026) and premature rupture of membranes (OR = 1.17, 95% CI 1.05-1.30, P = 0.004). Similar results were obtained for preeclampsia-eclampsia from the MR-Egger method (OR = 1.32, 95% CI 1.06-1.64, P = 0.027) and for premature rupture of membranes from the weighted median method (OR = 1.22, 95% CI 1.06-1.41, P = 0.006). No significant causal effects were found for other outcomes. There was no obvious heterogeneity and horizontal pleiotropy across the MR analysis.
UNASSIGNED: Our two-sample MR study demonstrated a causal relationship of H. pylori infection with preeclampsia-eclampsia and premature rupture of membranes. The findings confirm the epidemiological evidence on the adverse impact of H. pylori in pregnancy. Further studies are needed to elucidate the pathophysiological mechanisms and assess the effectiveness of pre-pregnancy screening and preventive eradication.
UNASSIGNED: A two-sample Mendelian randomization (MR) study was performed using summary-level statistics for anti-H. pylori IgG levels from the Avon Longitudinal Study of Parents and Children Cohort. Outcome data for pregnancy (miscarriage, preeclampsia-eclampsia, gestational diabetes mellitus, placental abruption, premature rupture of membranes, postpartum hemorrhage) and neonates (birthweight, gestational age, and preterm birth) were sourced from genome-wide association meta-analysis as well as the FinnGen and Early Growth Genetics Consortium. Causal estimates were calculated by five methods including inverse variance weighted (IVW). The heterogeneity of instrumental variables was quantified by Cochran\'s Q test, while sensitivity analyses were performed via MR-Egger, MR-PRESSO, and leave-one-out tests.
UNASSIGNED: IVW estimates suggested that genetically predicted anti-H. pylori IgG levels were significantly associated with increased risks of preeclampsia-eclampsia (odds ratio [OR] = 1.12, 95% confidence interval [CI] 1.01-1.24, P = 0.026) and premature rupture of membranes (OR = 1.17, 95% CI 1.05-1.30, P = 0.004). Similar results were obtained for preeclampsia-eclampsia from the MR-Egger method (OR = 1.32, 95% CI 1.06-1.64, P = 0.027) and for premature rupture of membranes from the weighted median method (OR = 1.22, 95% CI 1.06-1.41, P = 0.006). No significant causal effects were found for other outcomes. There was no obvious heterogeneity and horizontal pleiotropy across the MR analysis.
UNASSIGNED: Our two-sample MR study demonstrated a causal relationship of H. pylori infection with preeclampsia-eclampsia and premature rupture of membranes. The findings confirm the epidemiological evidence on the adverse impact of H. pylori in pregnancy. Further studies are needed to elucidate the pathophysiological mechanisms and assess the effectiveness of pre-pregnancy screening and preventive eradication.
摘要：
■观察性研究报道幽门螺杆菌(H.pylori）感染与一系列妊娠和新生儿结局有关。然而,结果不一致，因果关系未知。
■使用抗H.来自雅芳父母和儿童队列纵向研究的幽门螺杆菌IgG水平。妊娠结局数据(流产，先兆子痫-子痫,妊娠期糖尿病,胎盘早剥,胎膜早破,产后出血)和新生儿(出生体重，胎龄,和早产）来自全基因组关联荟萃分析以及FinnGen和早期生长遗传学联盟。因果估计通过五种方法计算，包括逆方差加权(IVW)。工具变量的异质性通过Cochran的Q检验进行量化，虽然敏感性分析是通过MR-Egger进行的，MR-PRESSO,和遗漏一次测试。
■IVW估计表明遗传预测抗H。幽门螺杆菌IgG水平与子痫前期-子痫的风险增加(比值比[OR]=1.12,95%置信区间[CI]1.01-1.24,P=0.026)和胎膜早破(OR=1.17,95%CI1.05-1.30,P=0.004)显著相关。通过MR-Egger方法（OR=1.32，95％CI1.06-1.64，P=0.027）和加权中位数方法（OR=1.22，95％CI1.06-1.41，P=0.006）获得了类似的结果。对其他结果没有发现显著的因果效应。在整个MR分析中没有明显的异质性和水平多效性。
■我们的双样本MR研究表明幽门螺杆菌感染与先兆子痫-子痫和胎膜早破之间存在因果关系。研究结果证实了关于幽门螺杆菌对妊娠的不利影响的流行病学证据。需要进一步的研究来阐明病理生理机制，并评估孕前筛查和预防性根除的有效性。
■使用抗H.来自雅芳父母和儿童队列纵向研究的幽门螺杆菌IgG水平。妊娠结局数据(流产，先兆子痫-子痫,妊娠期糖尿病,胎盘早剥,胎膜早破,产后出血)和新生儿(出生体重，胎龄,和早产）来自全基因组关联荟萃分析以及FinnGen和早期生长遗传学联盟。因果估计通过五种方法计算，包括逆方差加权(IVW)。工具变量的异质性通过Cochran的Q检验进行量化，虽然敏感性分析是通过MR-Egger进行的，MR-PRESSO,和遗漏一次测试。
■IVW估计表明遗传预测抗H。幽门螺杆菌IgG水平与子痫前期-子痫的风险增加(比值比[OR]=1.12,95%置信区间[CI]1.01-1.24,P=0.026)和胎膜早破(OR=1.17,95%CI1.05-1.30,P=0.004)显著相关。通过MR-Egger方法（OR=1.32，95％CI1.06-1.64，P=0.027）和加权中位数方法（OR=1.22，95％CI1.06-1.41，P=0.006）获得了类似的结果。对其他结果没有发现显著的因果效应。在整个MR分析中没有明显的异质性和水平多效性。
■我们的双样本MR研究表明幽门螺杆菌感染与先兆子痫-子痫和胎膜早破之间存在因果关系。研究结果证实了关于幽门螺杆菌对妊娠的不利影响的流行病学证据。需要进一步的研究来阐明病理生理机制，并评估孕前筛查和预防性根除的有效性。
