PDF(Pubmed)
Abstract：
Daptomycin-induced eosinophilic pneumonia (DIEP) is a rare but serious complication associated with the use of this broad-spectrum antibiotic. We present the case of a teenager with a history of nasopharyngeal cancer who developed DIEP while receiving daptomycin to treat an infection associated with an implanted chamber catheter. Symptoms included recurrent dyspnea and peripheral eosinophilia, with radiological findings consistent with DIEP. The pathophysiology involves an immune response triggered by daptomycin, resulting in eosinophilic pulmonary inflammation. Diagnosis requires a thorough evaluation of medical history, clinical laboratory tests, and radiological findings. The main treatment involves discontinuation of daptomycin and, in severe cases, the use of steroids. It is essential to consider DIEP in patients with respiratory failure and bilateral pulmonary opacities who have used daptomycin and to suspect it in those with blood eosinophilia or in bronchoalveolar lavage.
摘要：
达托霉素诱导的嗜酸性粒细胞肺炎（DIEP）是一种罕见但严重的并发症，与使用这种广谱抗生素有关。我们介绍了一名有鼻咽癌病史的青少年在接受达托霉素治疗与植入腔导管相关的感染时出现DIEP的情况。症状包括反复呼吸困难和外周嗜酸性粒细胞增多，放射学结果与DIEP一致。病理生理学涉及达托霉素引发的免疫反应，导致嗜酸性粒细胞性肺部炎症。诊断需要彻底评估病史,临床实验室检查,和放射学发现。主要治疗包括停药达托霉素，在严重的情况下，使用类固醇。对于使用达托霉素的呼吸衰竭和双侧肺部混浊的患者，必须考虑DIEP，而对于嗜酸粒细胞增多或支气管肺泡灌洗的患者则应怀疑DIEP。
