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Abstract：
BACKGROUND: Locally delivered antibiotics are adjunctive therapies for the selective removal or inhibition of pathogenic microbes in combination with scaling and root planing (SRP) for the management of periodontitis.
OBJECTIVE: The primary objective of this study was to evaluate the effectiveness of tetracycline fibers against minocycline gel when used as local drug delivery in conjunction with SRP for treating periodontitis.
METHODS: This is a pilot randomized open single, blinded trial study comparing three treatment modalities: SRP with topical tetracycline fibers (SRP+T), SRP with topical minocycline HCL 2% gel (SRP+M), and SRP only as a control group. Probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) percentages were recorded at baseline, one month, and at the end of three months. The data were subjected to analysis using IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. Repeated measures ANOVA was used to compare the clinical outcomes between the three treatment groups, accounting for the repeated measurements at baseline, one month, and three months. A p-value less than 0.05 at a 95% confidence interval was deemed statistically significant.
RESULTS: There were statistically significant changes within the groups in all the clinical parameters, including pocket depth, clinical attachment loss, and bleeding on probing score, at different time intervals, with the greatest mean pocket depth changes seen in the tetracycline group after one month (mean changes = 1.4 mm, P < 0.001) and over three months (mean changes = 1.79 mm, p < 0.001). For clinical attachment loss, after one month, the highest improvement in clinical level was seen in the minocycline group (mean changes = 0.7mm, p < 0.05), and the overall improvement was seen in the control group (mean changes = 1.1mm, p < 0.05). The minocycline group showed greater mean changes in bleeding on probing percentage, with the greatest changes after one month (mean changes = 19.34%, p < 0.001) and over three months (mean changes = 26.42%, p <0.001). However, there was no significant difference between the groups.
CONCLUSIONS: Locally delivered tetracycline and minocycline gel are effective as adjuncts to SRP and may improve the healing outcome in the management of periodontitis.
OBJECTIVE: The primary objective of this study was to evaluate the effectiveness of tetracycline fibers against minocycline gel when used as local drug delivery in conjunction with SRP for treating periodontitis.
METHODS: This is a pilot randomized open single, blinded trial study comparing three treatment modalities: SRP with topical tetracycline fibers (SRP+T), SRP with topical minocycline HCL 2% gel (SRP+M), and SRP only as a control group. Probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) percentages were recorded at baseline, one month, and at the end of three months. The data were subjected to analysis using IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp. Repeated measures ANOVA was used to compare the clinical outcomes between the three treatment groups, accounting for the repeated measurements at baseline, one month, and three months. A p-value less than 0.05 at a 95% confidence interval was deemed statistically significant.
RESULTS: There were statistically significant changes within the groups in all the clinical parameters, including pocket depth, clinical attachment loss, and bleeding on probing score, at different time intervals, with the greatest mean pocket depth changes seen in the tetracycline group after one month (mean changes = 1.4 mm, P < 0.001) and over three months (mean changes = 1.79 mm, p < 0.001). For clinical attachment loss, after one month, the highest improvement in clinical level was seen in the minocycline group (mean changes = 0.7mm, p < 0.05), and the overall improvement was seen in the control group (mean changes = 1.1mm, p < 0.05). The minocycline group showed greater mean changes in bleeding on probing percentage, with the greatest changes after one month (mean changes = 19.34%, p < 0.001) and over three months (mean changes = 26.42%, p <0.001). However, there was no significant difference between the groups.
CONCLUSIONS: Locally delivered tetracycline and minocycline gel are effective as adjuncts to SRP and may improve the healing outcome in the management of periodontitis.
摘要：
背景：局部递送的抗生素是用于选择性去除或抑制病原微生物的辅助疗法，与牙垢和牙根平整（SRP）联合用于治疗牙周炎。
目的：本研究的主要目的是评估四环素纤维在与SRP联合用于治疗牙周炎的局部药物递送时对抗米诺环素凝胶的有效性。
方法：这是一个试验随机开放单，比较三种治疗方式的盲法试验研究：SRP与局部四环素纤维（SRP+T），SRP与外用盐酸米诺环素2%凝胶（SRP+M），和SRP仅作为对照组。探测袋深度(PPD),临床附着丧失(CAL)，基线时记录探查出血（BOP）百分比，一个月,三个月后.使用IBM公司对数据进行分析2019年发布。IBMSPSSStatisticsforWindows,版本26.0。Armonk,纽约：IBM公司重复测量ANOVA用于比较三个治疗组之间的临床结果，考虑基线的重复测量，一个月,还有三个月.在95%置信区间小于0.05的p值被认为是统计学显著的。
结果：组内所有临床参数均有统计学意义的变化，包括口袋深度，临床附着丧失，在探测分数上流血，在不同的时间间隔，1个月后四环素组的平均口袋深度变化最大（平均变化=1.4mm，P<0.001）和超过三个月（平均变化=1.79mm，p<0.001)。对于临床附着丧失，一个月后,临床水平的改善最高见于米诺环素组(平均变化=0.7mm,p<0.05)，对照组总体改善（平均变化=1.1mm，p<0.05)。二甲胺四环素组在探查时显示出更大的平均出血变化百分比，一个月后变化最大(平均变化=19.34%，p<0.001)和三个月以上(平均变化=26.42%，p<0.001)。然而,组间无显著差异。
结论：局部递送四环素和米诺环素凝胶作为SRP的辅助药物是有效的，并且可以改善牙周炎治疗的愈合效果。
目的：本研究的主要目的是评估四环素纤维在与SRP联合用于治疗牙周炎的局部药物递送时对抗米诺环素凝胶的有效性。
方法：这是一个试验随机开放单，比较三种治疗方式的盲法试验研究：SRP与局部四环素纤维（SRP+T），SRP与外用盐酸米诺环素2%凝胶（SRP+M），和SRP仅作为对照组。探测袋深度(PPD),临床附着丧失(CAL)，基线时记录探查出血（BOP）百分比，一个月,三个月后.使用IBM公司对数据进行分析2019年发布。IBMSPSSStatisticsforWindows,版本26.0。Armonk,纽约：IBM公司重复测量ANOVA用于比较三个治疗组之间的临床结果，考虑基线的重复测量，一个月,还有三个月.在95%置信区间小于0.05的p值被认为是统计学显著的。
结果：组内所有临床参数均有统计学意义的变化，包括口袋深度，临床附着丧失，在探测分数上流血，在不同的时间间隔，1个月后四环素组的平均口袋深度变化最大（平均变化=1.4mm，P<0.001）和超过三个月（平均变化=1.79mm，p<0.001)。对于临床附着丧失，一个月后,临床水平的改善最高见于米诺环素组(平均变化=0.7mm,p<0.05)，对照组总体改善（平均变化=1.1mm，p<0.05)。二甲胺四环素组在探查时显示出更大的平均出血变化百分比，一个月后变化最大(平均变化=19.34%，p<0.001)和三个月以上(平均变化=26.42%，p<0.001)。然而,组间无显著差异。
结论：局部递送四环素和米诺环素凝胶作为SRP的辅助药物是有效的，并且可以改善牙周炎治疗的愈合效果。
