PDF(Pubmed)
Abstract：
OBJECTIVE: Unsafe opioid-related practices can lead to abuse, diversion, and accidental overdoses. In this study, we aimed to describe the patterns and beliefs regarding the storage, disposal, and use of opioids among Chinese patients with cancer in their home settings, which remain unclear.
METHODS: A multicenter cross-sectional survey was conducted in Hubei Province from October 2022 to June 2023. We collected information on the storage, disposal, and use of opioids among cancer pain inpatients in the oncology department. Logistic regression was used to estimate the factors associated with unsafe disposal and use of opioids.
RESULTS: The survey included 221 patients with a median age of 62 years. Only 3.2% stored their opioids under lock and key, and 49.8% were unaware of proper disposal methods. Nearly one-fifth (19.5%) reported having received information on the safe storage (14.0%) and/or disposal (10.0%) of opioids. A total of 44.3% reported unsafe use by sharing (1.8%), losing (4.1%), or taking opioids at a higher dose than prescribed (42.5%). Patients who did not receive information on the safe disposal of opioids (OR = 4.57, P = .0423), had a history of alcohol use (OR = 1.91, P = .0399), and used opioids other than morphine (OR = 2.31, P = .0461) had higher odds of unsafe disposal practices. Individuals with an associate degree/bachelor\'s degree or above were less likely to dispose of (OR = 0.36, P = .0261) and use (OR = 0.31, P = .0127) opioids unsafely.
CONCLUSIONS: A significant proportion of Chinese patients with cancer exhibit unsafe practices in the storage, disposal, and use of opioids. The study highlights an urgent need for implementing routine education programs and drug \"take-back\" initiatives to improve opioid-related practices.
METHODS: A multicenter cross-sectional survey was conducted in Hubei Province from October 2022 to June 2023. We collected information on the storage, disposal, and use of opioids among cancer pain inpatients in the oncology department. Logistic regression was used to estimate the factors associated with unsafe disposal and use of opioids.
RESULTS: The survey included 221 patients with a median age of 62 years. Only 3.2% stored their opioids under lock and key, and 49.8% were unaware of proper disposal methods. Nearly one-fifth (19.5%) reported having received information on the safe storage (14.0%) and/or disposal (10.0%) of opioids. A total of 44.3% reported unsafe use by sharing (1.8%), losing (4.1%), or taking opioids at a higher dose than prescribed (42.5%). Patients who did not receive information on the safe disposal of opioids (OR = 4.57, P = .0423), had a history of alcohol use (OR = 1.91, P = .0399), and used opioids other than morphine (OR = 2.31, P = .0461) had higher odds of unsafe disposal practices. Individuals with an associate degree/bachelor\'s degree or above were less likely to dispose of (OR = 0.36, P = .0261) and use (OR = 0.31, P = .0127) opioids unsafely.
CONCLUSIONS: A significant proportion of Chinese patients with cancer exhibit unsafe practices in the storage, disposal, and use of opioids. The study highlights an urgent need for implementing routine education programs and drug \"take-back\" initiatives to improve opioid-related practices.
摘要：
目标：不安全的阿片类药物相关做法可能导致滥用，分流,和意外用药过量。在这项研究中,我们旨在描述有关存储的模式和信念，处置,中国癌症患者在家中使用阿片类药物，尚不清楚。
方法：于2022年10月至2023年6月在湖北省进行了多中心横断面调查。我们收集了仓库的信息,处置,以及在肿瘤科癌症疼痛住院患者中使用阿片类药物。Logistic回归用于评估与阿片类药物的不安全处置和使用相关的因素。
结果：调查包括221名患者，中位年龄为62岁。只有3.2%的人把阿片类药物锁在钥匙下，49.8%的人不知道适当的处置方法。近五分之一(19.5%)的人报告收到了阿片类药物安全储存(14.0%)和/或处置(10.0%)的信息。共有44.3%的人报告共享使用不安全(1.8%)，亏损（4.1%），或服用阿片类药物的剂量高于处方（42.5%）。未获得阿片类药物安全处置信息的患者（OR=4.57，P=.0423），有饮酒史（OR=1.91，P=.0399），使用吗啡以外的阿片类药物（OR=2.31，P=.0461）的不安全处置方法的可能性更高。具有副学士学位/学士学位或以上学位的人不太可能不安全地处置（OR=0.36，P=.0261）和使用（OR=0.31，P=.0127）阿片类药物。
结论：相当比例的中国癌症患者在储存过程中表现出不安全的做法，处置,和使用阿片类药物。该研究强调迫切需要实施常规教育计划和药物“收回”举措，以改善与阿片类药物相关的做法。
方法：于2022年10月至2023年6月在湖北省进行了多中心横断面调查。我们收集了仓库的信息,处置,以及在肿瘤科癌症疼痛住院患者中使用阿片类药物。Logistic回归用于评估与阿片类药物的不安全处置和使用相关的因素。
结果：调查包括221名患者，中位年龄为62岁。只有3.2%的人把阿片类药物锁在钥匙下，49.8%的人不知道适当的处置方法。近五分之一(19.5%)的人报告收到了阿片类药物安全储存(14.0%)和/或处置(10.0%)的信息。共有44.3%的人报告共享使用不安全(1.8%)，亏损（4.1%），或服用阿片类药物的剂量高于处方（42.5%）。未获得阿片类药物安全处置信息的患者（OR=4.57，P=.0423），有饮酒史（OR=1.91，P=.0399），使用吗啡以外的阿片类药物（OR=2.31，P=.0461）的不安全处置方法的可能性更高。具有副学士学位/学士学位或以上学位的人不太可能不安全地处置（OR=0.36，P=.0261）和使用（OR=0.31，P=.0127）阿片类药物。
结论：相当比例的中国癌症患者在储存过程中表现出不安全的做法，处置,和使用阿片类药物。该研究强调迫切需要实施常规教育计划和药物“收回”举措，以改善与阿片类药物相关的做法。
