Abstract：
The objective of this meta-analysis is to investigate the association between air pollution and the vulnerability of children to autism spectrum disorders (ASD). A thorough examination and analysis of data obtained from a compilation of 14 studies was undertaken, with a particular emphasis on investigating the effects of nitrogen dioxide (NO2), oxide of nitrogen (NOx), ozone (O3), and particulate matter (PM10 and PM2.5) on individuals diagnosed with ASD. The findings demonstrate a moderate association between exposure to nitrogen dioxide (NO2) and ASD, as indicated by a combined odds ratio (OR) of 1.13 and a 95% confidence interval (CI) spanning from 0.77 to 1.549. O3 shows a combined odds ratio (OR) of 0.82, along with a 95% confidence interval (CI) ranging from 0.49 to 1.14. NOx shows a moderate level of heterogeneity (I² = 75.9%, p = 0.002), suggesting that the impact of NOx on the risk of ASD. There is a statistically significant relationship between exposure to O3 and ASD, although the strength of this relationship is diminished. The findings demonstrated a noteworthy correlation between exposure to PM10 and PM2.5 and the occurrence of ASD. The study found a significant correlation, in relation to PM2.5, with a combined odds ratio (OR) of 1.22 and a 95% confidence interval (CI) ranging from 1.11 to 1.34. The findings have significant implications for the formulation of programs aimed at reducing exposure to harmful chemicals, especially among vulnerable groups such as children.
摘要：
这项荟萃分析的目的是调查空气污染与儿童对自闭症谱系障碍（ASD）的脆弱性之间的关系。对从14项研究汇编中获得的数据进行了彻底的检查和分析，特别强调研究二氧化氮(NO2)的影响，氮氧化物（NOx），臭氧(O3)和颗粒物（PM10和PM2.5）对诊断为ASD的个体。研究结果表明，暴露于二氧化氮（NO2）和ASD之间存在中度关联，综合比值比(OR)为1.13,95%置信区间(CI)为0.77~1.549.O3显示出0.82的组合比值比（OR），以及从0.49到1.14的95％置信区间（CI）。NOx表现出中等水平的异质性(I²=75.9%，p=0.002),表明NOx对ASD风险的影响。暴露于O3和ASD之间存在统计学上的显着关系，尽管这种关系的强度减弱了。研究结果表明，暴露于PM10和PM2.5与ASD的发生之间存在值得注意的相关性。这项研究发现了显著的相关性，与PM2.5相关，综合比值比（OR）为1.22，95%置信区间（CI）为1.11至1.34。这些发现对制定旨在减少有害化学物质接触的计划具有重要意义，特别是儿童等弱势群体。
