Abstract：
UNASSIGNED: Central nervous system (CNS)-related disorders are increasingly being recognized as a global health challenge worldwide. There are significant challenges for effective diagnosis and treatment due to the presence of the CNS barriers which impede the management of neurological diseases. Combination of nanovesicles (NVs) and magnetic nanoparticles (MNPs), referred to as magnetic nanovesicles (MNVs), is now well suggested as a potential theranostic option for improving the management of neurological disorders with increased targeting efficiency and minimized side effects.
UNASSIGNED: This review provides a summary of major CNS disorders and the physical barriers limiting the access of imaging/therapeutic agents to the CNS environment. A special focus on the unique features of MNPs and NV is discussed which make them attractive candidates for neuro-nanomedicine. Furthermore, a deeper understanding of MNVs as a promising combined strategy for diagnostic and/or therapeutic purposes in neurological disorders is provided.
UNASSIGNED: The multifunctionality of MNVs offers the ability to overcome the CNS barriers and can be used to monitor the effectiveness of treatment. The insights provided will guide future research toward better outcomes and facilitate the development of next-generation, innovative treatments for CNS disorders.
UNASSIGNED: This review provides a summary of major CNS disorders and the physical barriers limiting the access of imaging/therapeutic agents to the CNS environment. A special focus on the unique features of MNPs and NV is discussed which make them attractive candidates for neuro-nanomedicine. Furthermore, a deeper understanding of MNVs as a promising combined strategy for diagnostic and/or therapeutic purposes in neurological disorders is provided.
UNASSIGNED: The multifunctionality of MNVs offers the ability to overcome the CNS barriers and can be used to monitor the effectiveness of treatment. The insights provided will guide future research toward better outcomes and facilitate the development of next-generation, innovative treatments for CNS disorders.
摘要：
中枢神经系统（CNS）相关疾病在全球范围内日益被视为全球健康挑战。由于CNS屏障的存在阻碍神经疾病的管理,对于有效的诊断和治疗存在重大挑战。纳米囊泡（NVs）和磁性纳米颗粒（MNPs）的组合，称为磁性纳米囊泡（MNV），现在被认为是一种潜在的治疗选择，用于改善神经系统疾病的管理，提高靶向效率和减少副作用。
■这篇综述概述了主要的中枢神经系统疾病和限制成像/治疗剂进入中枢神经系统环境的物理障碍。讨论了对MNPs和NV的独特功能的特别关注，这使它们成为神经纳米医学的有吸引力的候选者。此外，提供了对MNV作为用于神经障碍的诊断和/或治疗目的的有希望的组合策略的更深入的理解。
■MNV的多功能性提供了克服CNS障碍的能力，可用于监测治疗的有效性。提供的见解将指导未来的研究取得更好的成果，并促进下一代的发展。中枢神经系统疾病的创新治疗。
■这篇综述概述了主要的中枢神经系统疾病和限制成像/治疗剂进入中枢神经系统环境的物理障碍。讨论了对MNPs和NV的独特功能的特别关注，这使它们成为神经纳米医学的有吸引力的候选者。此外，提供了对MNV作为用于神经障碍的诊断和/或治疗目的的有希望的组合策略的更深入的理解。
■MNV的多功能性提供了克服CNS障碍的能力，可用于监测治疗的有效性。提供的见解将指导未来的研究取得更好的成果，并促进下一代的发展。中枢神经系统疾病的创新治疗。
