PDF(Pubmed)
Abstract：
Pressure monitoring in various organs of the body is essential for appropriate diagnostic and therapeutic purposes. In almost all situations, monitoring is performed in a hospital setting. Technological advances not only promise to improve clinical pressure monitoring systems, but also engage toward the development of fully implantable systems in ambulatory patients. Such systems would not only provide longitudinal time monitoring to healthcare personnel, but also to the patient who could adjust their way-of-life in response to the measurements. In the past years, we have developed a new type of piezoresistive pressure sensor system. Different bench tests have demonstrated that it delivers precise and reliable pressure measurements in real-time. The potential of this system was confirmed by a continuous recording in a patient that lasted for almost a day. In the present study, we further characterized the functionality of this sensor system by conducting in vivo implantation experiments in nine female farm pigs. To get a step closer to a fully implantable system, we also adapted two different wireless communication solutions to the sensor system. The communication protocols are based on MICS (Medical Implant Communication System) and BLE (Bluetooth Low Energy) communication. As a proof-of-concept, implantation experiments in nine female pigs demonstrated the functionality of both systems, with a notable technical superiority of the BLE.
摘要：
身体各个器官中的压力监测对于适当的诊断和治疗目的至关重要。在几乎所有情况下,监测是在医院环境中进行的。技术进步不仅有望改善临床压力监测系统，而且还致力于在非卧床患者中开发完全可植入系统。这样的系统不仅可以为医护人员提供纵向时间监控，而且对那些可以根据测量结果调整生活方式的患者也是如此。在过去的几年里,我们开发了一种新型的压阻式压力传感器系统。不同的台架测试表明，它可以实时提供精确可靠的压力测量。该系统的潜力通过持续近一天的患者连续记录得到证实。在本研究中,我们通过在9只雌性农场猪中进行体内植入实验，进一步表征了该传感器系统的功能。为了离完全可植入系统更近一步，我们还采用了两种不同的无线通信解决方案的传感器系统。通信协议基于MICS(医疗植入物通信系统)和BLE(蓝牙低功耗)通信。作为一个概念证明,九头母猪的植入实验证明了这两个系统的功能，具有显著的BLE技术优势。
