Abstract：
BACKGROUND: This paper highlights the relationship of inflammation and oxidative stress as damage mechanisms of Multiple Sclerosis (MS), considered an inflammatory and autoimmune disease.
METHODS: The oxidative stress concept has been defined by an imbalance between oxidants and antioxidants in favor of the oxidants. There is necessary to do physiological functions, like the respiration chain, but in certain conditions, the production of reactive species overpassed the antioxidant systems, which could cause tissue damage. On the other hand, it is well established that inflammation is a complex reaction in the vascularized connective tissue in response to diverse stimuli. However, an unregulated prolonged inflammatory process also can induce tissue damage.
CONCLUSIONS: Both inflammation and oxidative stress are interrelated since one could promote the other, leading to a toxic feedback system, which contributes to the inflammatory and demyelination process in MS.
METHODS: The oxidative stress concept has been defined by an imbalance between oxidants and antioxidants in favor of the oxidants. There is necessary to do physiological functions, like the respiration chain, but in certain conditions, the production of reactive species overpassed the antioxidant systems, which could cause tissue damage. On the other hand, it is well established that inflammation is a complex reaction in the vascularized connective tissue in response to diverse stimuli. However, an unregulated prolonged inflammatory process also can induce tissue damage.
CONCLUSIONS: Both inflammation and oxidative stress are interrelated since one could promote the other, leading to a toxic feedback system, which contributes to the inflammatory and demyelination process in MS.
摘要：
背景：本文强调了炎症和氧化应激作为多发性硬化（MS）损伤机制的关系，被认为是一种炎症和自身免疫性疾病。
方法：氧化应激概念已被定义为氧化剂和抗氧化剂之间的不平衡，有利于氧化剂。有必要做生理功能，就像呼吸链,但在某些条件下,反应性物种的产生超过了抗氧化剂系统，会导致组织损伤.另一方面,众所周知，炎症是血管化结缔组织中响应多种刺激的复杂反应。然而,不受调节的延长的炎症过程也可以诱导组织损伤。
结论：炎症和氧化应激是相互关联的，因为一个可以促进另一个，导致有毒的反馈系统，这有助于MS的炎症和脱髓鞘过程。
方法：氧化应激概念已被定义为氧化剂和抗氧化剂之间的不平衡，有利于氧化剂。有必要做生理功能，就像呼吸链,但在某些条件下,反应性物种的产生超过了抗氧化剂系统，会导致组织损伤.另一方面,众所周知，炎症是血管化结缔组织中响应多种刺激的复杂反应。然而,不受调节的延长的炎症过程也可以诱导组织损伤。
结论：炎症和氧化应激是相互关联的，因为一个可以促进另一个，导致有毒的反馈系统，这有助于MS的炎症和脱髓鞘过程。
