Abstract：
OBJECTIVE: Covid-19 has affected all people, especially those with chronic diseases, including Parkinson\'s Disease (PD). Covid-19 may affect both motor and neuropsychiatric symptoms of PD patients. We intend to evaluate different aspects of Covid-19 impact on PD patients.
METHODS: 647 PD patients were evaluated in terms of PD-related and Covid-19-related clinical presentations in addition to past medical history during the pandemic through an online questioner. They were compared with an age-matched control group consist of 673 individuals and a sample of the normal population consist of 1215 individuals.
RESULTS: The prevalence of Covid-19 in PD patients was 11.28%. The mortality was 1.23% among PD patients. The prevalence of Covid-19 in PD patients who undergone Deep Brain Stimulation (DBS) was 18.18%. No significant association was found between the duration of disease and the prevalence of Covid-19. A statistically significant higher prevalence of Covid-19 in PD patients who had direct contact with SARS-CoV-19 infected individuals was found. No statistically significant association has been found between the worsening of motor symptoms and Covid-19. PD patients and the normal population may differ in the prevalence of some psychological disorders, including anxiety and sleeping disorders, and Covid-19 may affect the psychological status.
CONCLUSIONS: PD patients possibly follow tighter preventive protocols, which lead to lower prevalence and severity of Covid-19 and its consequences in these patients. Although it seems Covid-19 does not affect motor and psychological aspects of PD as much as it was expected, more accurate evaluations are suggested in order to clarify such effects.
METHODS: 647 PD patients were evaluated in terms of PD-related and Covid-19-related clinical presentations in addition to past medical history during the pandemic through an online questioner. They were compared with an age-matched control group consist of 673 individuals and a sample of the normal population consist of 1215 individuals.
RESULTS: The prevalence of Covid-19 in PD patients was 11.28%. The mortality was 1.23% among PD patients. The prevalence of Covid-19 in PD patients who undergone Deep Brain Stimulation (DBS) was 18.18%. No significant association was found between the duration of disease and the prevalence of Covid-19. A statistically significant higher prevalence of Covid-19 in PD patients who had direct contact with SARS-CoV-19 infected individuals was found. No statistically significant association has been found between the worsening of motor symptoms and Covid-19. PD patients and the normal population may differ in the prevalence of some psychological disorders, including anxiety and sleeping disorders, and Covid-19 may affect the psychological status.
CONCLUSIONS: PD patients possibly follow tighter preventive protocols, which lead to lower prevalence and severity of Covid-19 and its consequences in these patients. Although it seems Covid-19 does not affect motor and psychological aspects of PD as much as it was expected, more accurate evaluations are suggested in order to clarify such effects.
摘要：
目标：Covid-19影响了所有人，尤其是那些患有慢性病的人，包括帕金森病（PD）。Covid-19可能会影响PD患者的运动和神经精神症状。我们打算评估新冠肺炎对PD患者影响的不同方面。
方法：647名PD患者通过在线提问者评估了大流行期间PD相关和Covid-19相关的临床表现以及既往病史。将它们与由673个人组成的年龄匹配的对照组和由1215个人组成的正常人群样本进行比较。
结果：PD患者中Covid-19的患病率为11.28%。PD患者死亡率为1.23%。接受深部脑刺激(DBS)的PD患者中Covid-19的患病率为18.18%。在疾病持续时间和新冠肺炎的患病率之间没有发现显著的关联。在与SARS-CoV-19感染者直接接触的PD患者中，Covid-19的患病率在统计学上显着较高。在运动症状恶化和新冠肺炎之间没有发现统计学上的显著关联。PD患者和正常人群在某些心理障碍的患病率上可能存在差异，包括焦虑和睡眠障碍，Covid-19可能会影响心理状态。
结论：PD患者可能遵循更严格的预防方案，这导致Covid-19的患病率和严重程度及其在这些患者中的后果较低。虽然新冠肺炎似乎没有像预期的那样影响PD的运动和心理方面，为了澄清这种影响，建议进行更准确的评估。
方法：647名PD患者通过在线提问者评估了大流行期间PD相关和Covid-19相关的临床表现以及既往病史。将它们与由673个人组成的年龄匹配的对照组和由1215个人组成的正常人群样本进行比较。
结果：PD患者中Covid-19的患病率为11.28%。PD患者死亡率为1.23%。接受深部脑刺激(DBS)的PD患者中Covid-19的患病率为18.18%。在疾病持续时间和新冠肺炎的患病率之间没有发现显著的关联。在与SARS-CoV-19感染者直接接触的PD患者中，Covid-19的患病率在统计学上显着较高。在运动症状恶化和新冠肺炎之间没有发现统计学上的显著关联。PD患者和正常人群在某些心理障碍的患病率上可能存在差异，包括焦虑和睡眠障碍，Covid-19可能会影响心理状态。
结论：PD患者可能遵循更严格的预防方案，这导致Covid-19的患病率和严重程度及其在这些患者中的后果较低。虽然新冠肺炎似乎没有像预期的那样影响PD的运动和心理方面，为了澄清这种影响，建议进行更准确的评估。
