PDF(Pubmed)
Abstract：
Myocardial injury in the context of septic shock presents a multifaceted challenge in critical care medicine with implications for patient prognosis and therapeutic strategies. This comprehensive review explores the mechanisms, diagnostic approaches, and clinical implications of myocardial injury as a harbinger of multi-organ failure in septic shock. We delineate the pathophysiological processes underlying myocardial injury, including inflammation, oxidative stress, and microcirculatory dysfunction, and discuss the diagnostic utility of cardiac biomarkers and imaging modalities in identifying myocardial injury. Furthermore, we elucidate the prognostic significance of myocardial injury and its implications for patient management, highlighting the need for tailored therapeutic interventions to mitigate its adverse effects. Future research and clinical practice directions are also discussed, emphasizing the importance of personalized medicine approaches and multidisciplinary collaboration in optimizing outcomes for patients with septic shock-associated myocardial injury. This review aims to provide a comprehensive understanding of myocardial injury in septic shock and inform strategies for improving patient care in this challenging clinical scenario.
摘要：
感染性休克背景下的心肌损伤在重症监护医学中提出了多方面的挑战，对患者的预后和治疗策略有影响。这次全面审查探讨了机制，诊断方法，心肌损伤作为感染性休克多器官衰竭的先兆的临床意义。我们描述了心肌损伤的病理生理过程，包括炎症,氧化应激，和微循环功能障碍，并讨论心脏生物标志物和成像方式在识别心肌损伤中的诊断实用性。此外，我们阐明了心肌损伤的预后意义及其对患者管理的影响，强调需要有针对性的治疗干预措施来减轻其不利影响。还讨论了未来的研究和临床实践方向，强调个性化医疗方法和多学科合作在优化感染性休克相关心肌损伤患者预后方面的重要性.这篇综述旨在全面了解脓毒性休克中的心肌损伤，并告知在这种具有挑战性的临床情况下改善患者护理的策略。
