PDF(Pubmed)
Abstract：
Chronic spontaneous urticaria (CSU) is a dermatological disorder accompanied by itching that greatly affects the quality of life and quality of sleep. Therefore, it is assumed that CSU patients consequently experience reduced melatonin secretion and lower values of serum or salivary melatonin. This pilot study included 20 patients with CSU (chronic urticaria of unknown etiology that lasts for more than 6 weeks) and 10 healthy controls. All subjects were examined by a dermatovenereologist-allergist, as well as an oral pathologist, to exclude oral pathological conditions. Salivary melatonin levels were determined by ELISA and all subjects completed a standardized Dermatology Life Quality Index questionnaire and Pittsburgh Sleep Quality Index on the same day they gave a saliva sample for analysis. According to our results, 86% of CSU patients had decreased values of salivary melatonin, and lower salivary melatonin values significantly correlated with a reduced quality of life in CSU patients. This study was the first to analyze melatonin in CSU patients, also suggesting a possible new therapeutic option for the treatment of CSU.
摘要：
慢性自发性荨麻疹（CSU）是一种皮肤病，伴有瘙痒，极大地影响生活质量和睡眠质量。因此,假设CSU患者因此经历褪黑素分泌减少和血清或唾液褪黑素值降低。这项初步研究包括20名CSU患者（病因不明，持续超过6周的慢性荨麻疹）和10名健康对照。所有受试者均由皮肤性病变态反应医师检查，以及口腔病理学家，排除口腔疾病。通过ELISA测定唾液褪黑激素水平,并且所有受试者在给予唾液样品进行分析的同一天完成标准化皮肤病学生活质量指数问卷和匹兹堡睡眠质量指数。根据我们的结果,86％的CSU患者唾液褪黑素值降低，和唾液褪黑素值较低与CSU患者生活质量下降显著相关。这项研究首次分析了CSU患者的褪黑激素，还提出了一种治疗CSU的可能的新治疗选择。
