Abstract:
It is over 60 years since Paul Cibis et al. reported the experimental use of liquid silicone in the surgical management of retinal detachment. Initial experiences were complicated by significant side-effects associated with the impurities in the non-medical grade commercial silicone oils deployed at the time. These were substantially reduced (but not eliminated) by the adoption of refined high-viscosity medical grade silicone oils. Two of the major complications associated with silicone tamponade are (i) the variability of focus due to its movement and higher refractive index, and (ii) progressive emulsification, particularly with low viscosity oils. This article reviews recent and ongoing research on the causes of emulsification of intra-ocular silicone oil to understand the causes better and thereby reduce this risk, especially for those eyes where permanent tamponade is the only current option for retaining vision.
摘要: 自Paul Cibis等人实验性地将液态硅油用于视网膜脱落的手术治疗以来, 已过去 60多年。由于当时使用的非医用级商业硅油中含有杂质, 会产生严重副作用, 因此最初的经验难以确定。采用精制的高粘度医用级硅油后, 副作用大大减少 (但并未完全消除) 。与硅油填塞相关的两个主要并发症是: (i) 由于硅油的移动和较高折射率而导致眼部焦距变化;(ii) 硅油逐渐乳化, 尤其是低粘度硅油。本文回顾了近期和正在进行的关于眼内硅油乳化原因的研究, 以更好地了解其原因, 从而降低该风险, 尤其是对于那些病人来说永久性填塞是目前唯一保留视力的方法。.