Abstract：
The pathophysiology of hepatic encephalopathy (HE) is complex, with hyperammonemia playing a central role in its development. Traditional therapies for HE have targeted ammonia and include medications such as lactulose and rifaximin. Although these agents are considered standard of care, nontraditional treatments seek to affect other factors in the pathogenesis of HE. Finally, procedural therapies include albumin dialysis, shunt closure, and the ultimate cure for HE, which is liver transplant. The treatments discussed provide alternative options for patients who have failed standard of care. However, more high-quality studies are needed to routinely recommend many of these agents.
摘要：
肝性脑病（HE）的病理生理是复杂的，高氨血症在其发展中起着核心作用。HE的传统疗法具有靶向氨,并且包括药物如乳果糖和利福昔明。虽然这些药物被认为是护理标准，非传统治疗试图影响HE发病机制中的其他因素。最后,程序性治疗包括白蛋白透析，分流器闭合,和他的最终治疗方法，也就是肝移植.所讨论的治疗方法为护理标准失败的患者提供了替代选择。然而,需要更多高质量的研究来常规推荐这些药物.
