Abstract：
Rheumatoid arthritis (RA) is an autoimmune disease suffered by millions of people worldwide. It can significantly affect the patient\'s quality of life by damaging not only the joints but also organs such as the lungs and the heart. RA is normally treated using nonsteroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, disease-modifying antirheumatic drugs (DMARDs), and biologics. These active agents often cause side effects and offer low efficacy due to their lack of specificity and limited retention time. In an attempt to improve RA treatments, hydrogel-based systems have been proposed as drug delivery carriers. Due to their exceptional adaptability and biocompatibility, hydrogels have the potential of enhancing the delivery of RA therapy through different administration routes in an efficient and effective manner. In this review, we explore the application of hydrogel systems as potential carriers in RA treatment. Additionally, we discuss recent work in the field and highlight the required hydrogel properties, depending on the administration route. The outstanding potential of hydrogel systems as carriers for RA was demonstrated; however, there is extensive research yet to be done to improve available treatments for RA.
摘要：
类风湿性关节炎(RA)是全球数百万人遭受的自身免疫性疾病。它不仅会损伤关节，还会损伤肺和心脏等器官，从而显著影响患者的生活质量。RA通常使用非甾体抗炎药（NSAIDs）治疗，糖皮质激素,改善疾病的抗风湿药（DMARDs），和生物制品。由于缺乏特异性和有限的保留时间,这些活性剂通常引起副作用并提供低功效。为了改善RA治疗，已经提出基于水凝胶的系统作为药物递送载体。由于其特殊的适应性和生物相容性，水凝胶具有以有效和有效的方式通过不同给药途径增强RA治疗的递送的潜力。在这次审查中,我们探索水凝胶系统作为潜在载体在RA治疗中的应用。此外,我们讨论了该领域的最新工作，并强调了所需的水凝胶特性，取决于管理途径。证明了水凝胶系统作为RA载体的杰出潜力；然而，目前仍有大量的研究来改善RA的可用治疗方法.
