Abstract：
OBJECTIVE: Dental agenesis data in modern and premodern sub-Saharan Africans are presented by region, West, Central, East, and South, and by sex. Beyond characterizing the anomaly, comparisons are made with other populations and future work is encouraged. The findings should be of use to dental clinicians and anthropologists.
METHODS: Agenesis of the UI2, LI1, UP2, LP2, UM3, and LM3 was recorded in 52 discrete samples of mainly skeletal dentitions (n = 2162) from across the subcontinent. After dividing into temporal categories, regional pooling was effected for adequate sample sizes across the vast geographic area. Only adults were included to record M3 status. Analyses included 95% confidence intervals and chi-square comparisons by region and sex.
RESULTS: Of 1668 modern individuals 2.3% have UI2-LP2 agenesis (CI 1.6-3.1%). Regional and sex differences are non-significant, though females are most affected. For M3s it is 7.0% (5.7-8.4%), with the Central region sample differing significantly from the East and South. Females again have greater prevalence, with the difference in the West significant. UI2-LP2 agenesis affects 0.6% of 494 premodern individuals (0.1-1.8%), while M3 agenesis is 8.5% (6.1-11.5%). None of these differences are significant.
CONCLUSIONS: Rates are toward the low end of global ranges, including 0.0-12.6% for UI2-LP2 from case reports, and 5.3-56.0% for M3 agenesis. With exceptions, generally insignificant inter-region differences imply that rates reasonably represent sub-Saharan peoples overall. Results will be of interest to anthropologists, but those related to risk factors, patterning, and prevalence may assist clinicians in tailoring treatment, while informing patients how this anomaly differs by population ancestry.
METHODS: Agenesis of the UI2, LI1, UP2, LP2, UM3, and LM3 was recorded in 52 discrete samples of mainly skeletal dentitions (n = 2162) from across the subcontinent. After dividing into temporal categories, regional pooling was effected for adequate sample sizes across the vast geographic area. Only adults were included to record M3 status. Analyses included 95% confidence intervals and chi-square comparisons by region and sex.
RESULTS: Of 1668 modern individuals 2.3% have UI2-LP2 agenesis (CI 1.6-3.1%). Regional and sex differences are non-significant, though females are most affected. For M3s it is 7.0% (5.7-8.4%), with the Central region sample differing significantly from the East and South. Females again have greater prevalence, with the difference in the West significant. UI2-LP2 agenesis affects 0.6% of 494 premodern individuals (0.1-1.8%), while M3 agenesis is 8.5% (6.1-11.5%). None of these differences are significant.
CONCLUSIONS: Rates are toward the low end of global ranges, including 0.0-12.6% for UI2-LP2 from case reports, and 5.3-56.0% for M3 agenesis. With exceptions, generally insignificant inter-region differences imply that rates reasonably represent sub-Saharan peoples overall. Results will be of interest to anthropologists, but those related to risk factors, patterning, and prevalence may assist clinicians in tailoring treatment, while informing patients how this anomaly differs by population ancestry.
摘要：
目的：现代和前撒哈拉以南非洲人的牙齿发育数据按地区列出，西,中央,东,南,和性别。除了描述异常，与其他人群进行比较，鼓励未来的工作。这些发现应该对牙科临床医生和人类学家有用。
方法：将UI2、LI1、UP2、LP2、UM3和LM3的分布记录在来自整个次大陆的52个主要是骨骼牙列（n=2162）的离散样本中。在划分为时间类别之后，区域汇集是为了在广阔的地理区域内获得足够的样本量。仅包括成年人来记录M3状态。分析包括95%的置信区间和按地区和性别的卡方比较。
结果：在1668名现代个体中，2.3%患有UI2-LP2发育不全（CI1.6-3.1%）。地区和性别差异不显著，虽然女性受影响最大。对于M3s，它是7.0%（5.7-8.4%），中部地区的样本与东部和南部有很大不同。女性再次有更高的患病率，与西方差异显著。UI2-LP2发育不全影响了494名前现代个体中的0.6%(0.1-1.8%)，而M3发育不全为8.5%(6.1-11.5%)。这些差异都不显著。
结论：利率接近全球范围的低端，包括病例报告中UI2-LP2的0.0-12.6%，M3发育期为5.3-56.0%。除了例外,区域间差异一般微不足道，这意味着比率在总体上合理地代表了撒哈拉以南人民。结果会引起人类学家的兴趣，但是那些与风险因素有关的，图案化,和患病率可以帮助临床医生定制治疗，同时告知患者这种异常如何因人口祖先而异。
方法：将UI2、LI1、UP2、LP2、UM3和LM3的分布记录在来自整个次大陆的52个主要是骨骼牙列（n=2162）的离散样本中。在划分为时间类别之后，区域汇集是为了在广阔的地理区域内获得足够的样本量。仅包括成年人来记录M3状态。分析包括95%的置信区间和按地区和性别的卡方比较。
结果：在1668名现代个体中，2.3%患有UI2-LP2发育不全（CI1.6-3.1%）。地区和性别差异不显著，虽然女性受影响最大。对于M3s，它是7.0%（5.7-8.4%），中部地区的样本与东部和南部有很大不同。女性再次有更高的患病率，与西方差异显著。UI2-LP2发育不全影响了494名前现代个体中的0.6%(0.1-1.8%)，而M3发育不全为8.5%(6.1-11.5%)。这些差异都不显著。
结论：利率接近全球范围的低端，包括病例报告中UI2-LP2的0.0-12.6%，M3发育期为5.3-56.0%。除了例外,区域间差异一般微不足道，这意味着比率在总体上合理地代表了撒哈拉以南人民。结果会引起人类学家的兴趣，但是那些与风险因素有关的，图案化,和患病率可以帮助临床医生定制治疗，同时告知患者这种异常如何因人口祖先而异。
