Abstract：
Coordination and information exchange among the various organelles ensure the precise and orderly functioning of eukaryotic cells. Interaction between the cytoplasm and nucleoplasm is crucial for many physiological processes. Macromolecular protein transport into the nucleus requires assistance from the nuclear transport system. These proteins typically contain a nuclear localisation sequence that guides them to enter the nucleus. Understanding the mechanism of nuclear import of macromolecular proteins is important for comprehending cellular processes. Investigation of disease-related alterations can facilitate the development of novel therapeutic strategies and provide additional evidence for clinical trials. This review provides an overview of the proteins involved in nuclear transport and the mechanisms underlying macromolecular protein transport.
摘要：
各种细胞器之间的协调和信息交换确保了真核细胞的精确和有序功能。细胞质和核质之间的相互作用对于许多生理过程至关重要。大分子蛋白质转运到细胞核中需要核转运系统的帮助。这些蛋白质通常含有引导它们进入细胞核的核定位序列。了解大分子蛋白质的核导入机制对于理解细胞过程很重要。疾病相关改变的研究可以促进新的治疗策略的发展，并为临床试验提供额外的证据。这篇综述概述了参与核运输的蛋白质和大分子蛋白质运输的机制。
