PDF(Pubmed)
Abstract：
SUMMARYAs Chagas disease remains prevalent in the Americas, it is important that healthcare professionals and researchers are aware of the screening, diagnosis, monitoring, and treatment recommendations for the populations of patients they care for and study. Management of Trypanosoma cruzi infection in immunocompromised hosts is challenging, particularly because, regardless of antitrypanosomal treatment status, immunocompromised patients with Chagas disease are at risk for T. cruzi reactivation, which can be lethal. Evidence-based practices to prevent and manage T. cruzi reactivation vary depending on the type of immunocompromise. Here, we review available data describing Chagas disease epidemiology, testing, and management practices for various populations of immunocompromised individuals, including people with HIV and patients undergoing solid organ and hematopoietic stem cell transplantation.
摘要：
南美锥虫病在美洲仍然很普遍，重要的是，医疗保健专业人员和研究人员意识到筛查，诊断,监测,以及他们所关心和研究的患者人群的治疗建议。在免疫功能低下的宿主中管理克氏锥虫感染具有挑战性，特别是因为,无论抗锥虫治疗状态如何，免疫功能低下的查加斯病患者面临克氏锥虫再激活的风险，这可能是致命的。预防和管理克氏锥虫再激活的循证实践取决于免疫妥协的类型。这里,我们回顾了描述查加斯病流行病学的可用数据，测试,以及各种免疫功能低下个体人群的管理实践，包括艾滋病毒感染者和接受实体器官和造血干细胞移植的患者。
