PDF(Pubmed)
Abstract：
BACKGROUND: Effective vaccines for the prevention of cervical cancers are available in India. The existing knowledge and attitude regarding the Human Papillomavirus (HPV) vaccine varies widely among available studies. Our study aimed to estimate pooled prevalence related to knowledge, attitude, and practice of HPV vaccination in India.
METHODS: We conducted systematic searches in PUBMED, EMBASE, CINHAL, PROQUEST, and Cochrane Library databases using database-specific search strategies. The random effects model was used for estimating the pooled proportion of knowledge, attitude, and practice. The outlier studies were identified using the Baujat test. Egger\'s regression test and funnel plots were used to identify publication bias.
RESULTS: Database-specific search strategies yielded 2,377 records from five databases. We identified 48 studies for full-text retrieval after screening titles and abstracts. Finally, 27 studies were included in the meta-analysis. The pooled prevalence of knowledge regarding HPV vaccines in India was 0.22 (CI;0.14-0.31, I2 =99.5%). The pooled prevalence of positive attitudes towards the uptake of HPV vaccines in India was 0.45 (CI;0.33-0.57, I2 =100%). The pooled prevalence of coverage of HPV vaccines in India was 0.04 (CI;0.02-0.07, I2 =96%). Significant publication bias was present for the studies\' reported knowledge and coverage.
CONCLUSIONS: The knowledge, attitude, and coverage of the HPV vaccine were low in India. It suggests effective strategies to improve knowledge and attitudes towards HPV vaccination in India.
METHODS: We conducted systematic searches in PUBMED, EMBASE, CINHAL, PROQUEST, and Cochrane Library databases using database-specific search strategies. The random effects model was used for estimating the pooled proportion of knowledge, attitude, and practice. The outlier studies were identified using the Baujat test. Egger\'s regression test and funnel plots were used to identify publication bias.
RESULTS: Database-specific search strategies yielded 2,377 records from five databases. We identified 48 studies for full-text retrieval after screening titles and abstracts. Finally, 27 studies were included in the meta-analysis. The pooled prevalence of knowledge regarding HPV vaccines in India was 0.22 (CI;0.14-0.31, I2 =99.5%). The pooled prevalence of positive attitudes towards the uptake of HPV vaccines in India was 0.45 (CI;0.33-0.57, I2 =100%). The pooled prevalence of coverage of HPV vaccines in India was 0.04 (CI;0.02-0.07, I2 =96%). Significant publication bias was present for the studies\' reported knowledge and coverage.
CONCLUSIONS: The knowledge, attitude, and coverage of the HPV vaccine were low in India. It suggests effective strategies to improve knowledge and attitudes towards HPV vaccination in India.
摘要：
背景：印度有预防宫颈癌的有效疫苗。现有的关于人乳头瘤病毒（HPV）疫苗的知识和态度在现有研究中差异很大。我们的研究旨在估计与知识相关的合并患病率，态度,以及印度HPV疫苗接种的实践。
方法：我们在PUBMED中进行了系统搜索，EMBASE,CINHAL,PROQUEST,和CochraneLibrary数据库使用特定于数据库的搜索策略。随机效应模型用于估计知识的合并比例，态度,和实践。使用Baujat检验鉴定离群值研究。使用Egger回归检验和漏斗图识别发表偏倚。
结果：数据库特定的搜索策略从五个数据库中产生了2377条记录。筛选标题和摘要后，我们确定了48项全文检索研究。最后,27项研究纳入荟萃分析。印度HPV疫苗相关知识的汇总患病率为0.22（CI;0.14-0.31，I2=99.5％）。在印度，对HPV疫苗摄取的积极态度的汇总患病率为0.45（CI;0.33-0.57，I2=100％）。印度HPV疫苗的总覆盖率为0.04(CI;0.02-0.07,I2=96%)。研究报告的知识和覆盖率存在显著的发表偏倚。
结论：知识，态度,在印度，HPV疫苗的覆盖率很低。它提出了有效的策略，以提高印度对HPV疫苗接种的知识和态度。
方法：我们在PUBMED中进行了系统搜索，EMBASE,CINHAL,PROQUEST,和CochraneLibrary数据库使用特定于数据库的搜索策略。随机效应模型用于估计知识的合并比例，态度,和实践。使用Baujat检验鉴定离群值研究。使用Egger回归检验和漏斗图识别发表偏倚。
结果：数据库特定的搜索策略从五个数据库中产生了2377条记录。筛选标题和摘要后，我们确定了48项全文检索研究。最后,27项研究纳入荟萃分析。印度HPV疫苗相关知识的汇总患病率为0.22（CI;0.14-0.31，I2=99.5％）。在印度，对HPV疫苗摄取的积极态度的汇总患病率为0.45（CI;0.33-0.57，I2=100％）。印度HPV疫苗的总覆盖率为0.04(CI;0.02-0.07,I2=96%)。研究报告的知识和覆盖率存在显著的发表偏倚。
结论：知识，态度,在印度，HPV疫苗的覆盖率很低。它提出了有效的策略，以提高印度对HPV疫苗接种的知识和态度。
