PDF(Pubmed)
Abstract：
Cocaine is an indirect-acting sympathomimetic drug that inhibits norepinephrine and dopamine reuptake in the adrenergic presynaptic cleft. Cocaine use has been associated with strokes, angina, arrhythmias, and agitation. Data on gastrointestinal complications such as mesenteric ischemia, bowel necrosis, ulceration, and perforation are scarce. Here, we present a rare case of cocaine-induced esophageal, gastric, and small bowel necrosis that contributes to the limited literature on this subject. Diagnosis of cocaine-induced gastrointestinal complications involves a combination of imaging studies, laboratory assessments, and histopathological examinations. Timely surgical resection, supported by intravenous fluids, antibiotics, and pain management, is the mainstay of treatment. The prognosis varies but is significantly influenced by the promptness and effectiveness of the intervention, underscoring the importance of vigilant clinical care in such cases.
摘要：
可卡因是一种间接作用的拟交感神经药物，可抑制肾上腺素能突触前裂隙中的去甲肾上腺素和多巴胺再摄取。可卡因的使用与中风有关，心绞痛,心律失常,和激动。胃肠道并发症的数据，如肠系膜缺血，肠坏死,溃疡,穿孔很少。这里,我们介绍了一个罕见的可卡因诱导的食道，胃,和小肠坏死，这导致了关于这一主题的有限文献。可卡因引起的胃肠道并发症的诊断涉及影像学研究的组合，实验室评估,和组织病理学检查。及时手术切除,由静脉输液支持，抗生素,和疼痛管理，是治疗的支柱。预后各不相同，但受干预的及时性和有效性影响很大。强调在这种情况下警惕临床护理的重要性。
