Abstract：
In the study, we have shown the efficacy of an indigenously developed redox balancing chitosan gel with impregnated citrate capped Mn3O4 nanoparticles (nanogel). Application of the nanogel on a wound of preclinical mice model shows role of various signaling molecules and growth factors, and involvement of reactive oxygen species (ROS) at every stage, namely hemostasis, inflammation, and proliferation leading to complete maturation for the scarless wound healing. While in vitro characterization of nanogel using SEM, EDAX, and optical spectroscopy reveals pH regulated redox buffering capacity, in vivo preclinical studies on Swiss albino involving IL-12, IFN-γ, and α-SMA signaling molecules and detailed histopathological investigation and angiogenesis on every stage elucidate role of redox buffering for the complete wound healing process.
摘要：
在研究中,我们已经展示了一种本土开发的氧化还原平衡壳聚糖凝胶与浸渍柠檬酸盐覆盖的Mn3O4纳米颗粒（纳米凝胶）的功效。纳米凝胶在临床前小鼠模型伤口上的应用显示了各种信号分子和生长因子的作用，以及活性氧（ROS）在每个阶段的参与，即止血，炎症,和增殖导致无疤痕伤口愈合的完全成熟。虽然使用SEM对纳米凝胶进行了体外表征，EDAX,光谱学揭示了pH调节的氧化还原缓冲能力，涉及IL-12，IFN-γ的瑞士白化病的体内临床前研究，和α-SMA信号分子以及详细的组织病理学研究和每个阶段的血管生成阐明了氧化还原缓冲在完整伤口愈合过程中的作用。
