PDF(Pubmed)
Abstract：
Sparassis crispa, an edible mushroom, has been reported to show many kinds of physiological functions. The present paper focused on reducing body weight, subcutaneous fat, and visceral fat gain in ovariectomized (OVX) mice. Using the fruiting body powder of the indoor cultivation S. crispa (IT S. crispa: ITSc), one week after the OVX, ITSc was administered to two OVX groups by per os (p.o). In the sham group, 10 mL/kg water and 10 mL/kg saline were administered by p.o. and subcutaneous adm, respectively. OVX groups were divided into four groups. These treatments were performed on animals 6 days a week for 8 weeks. Subcutaneous and visceral fat measurements were performed under inhalation anesthesia with isoflurane using a Latheta LCT-200 X-ray CT system. The biochemical markers and the mRNA expression levels of the PPARγ, adiponectin, TNF-α, PPARα, and leptin were measured. Significant increases in body weight, fat ratio, and glucose levels were detected in OVX mice compared to sham mice. These increases were significantly blocked by ITSc, but not estradiol. Furthermore, ITSc treatment significantly increased adiponectin and leptin levels in adipose tissue. These results suggest that ITSc improves lipid abnormalities due to the less activity of women\'s ovary function, excluding estrogen functions.
摘要：
Sparasiscrispa，一种可食用的蘑菇，据报道显示多种生理功能。本文的重点是减轻体重，皮下脂肪,卵巢切除（OVX）小鼠的内脏脂肪增加。使用室内栽培S.crispa（ITS.crispa：ITSc）的子实体粉末，OVX一周后,ITSc通过口服给两个OVX组（p。a).在假小组中，通过口服和皮下给药10mL/kg水和10mL/kg盐水，分别。OVX组分为四组。对动物进行这些处理,每周6天,共8周。使用LathetaLCT-200X射线CT系统，在异氟烷吸入麻醉下进行皮下和内脏脂肪测量。PPARγ的生化标志物和mRNA表达水平，脂联素,TNF-α,PPARα,并测量了瘦素。体重显著增加，脂肪比例,与假手术小鼠相比,在OVX小鼠中检测到葡萄糖水平。这些增加被ITSc显著阻止，但不是雌二醇.此外，ITSc治疗显著增加脂肪组织中的脂联素和瘦素水平。这些结果表明，由于妇女的卵巢功能活动较少，ITSc可改善脂质异常，排除雌激素功能。
