PDF(Pubmed)
Abstract：
Infant colic is a common functional gastrointestinal disorder that affects infants during their first months of life. The etiology of this condition remains unclear. However, some studies suggest lactase deficiency may be a contributing factor. Currently, the evidence on dietary treatment and lactase supplementation for management of infant colic is limited. We aim to systematically review evidence on the efficacy and safety of using a lactase supplementation for managing infant colic. The Cochrane Central Register of Controlled Trials (CENTRAL, the Cochrane Library), MEDLINE, and EMBASE will be searched to identify randomized controlled trials comparing oral lactase supplementation with placebo or no intervention in infants aged less than 6-month-old with infant colic using any recognized definition. The risk of bias will be assessed using the second version of the Cochrane Collaboration\'s risk-of-bias tool. The main outcome will be the number of responders in each group after treatment, defined as infants who experienced a decrease in daily crying as reported by the study authors. Additional outcomes will include the duration and frequency of crying episodes, infant sleep duration, parental satisfaction, discomfort of infants, number of hospital admissions, family quality of life, and adverse events during the intervention. The study findings will be published in a peer-reviewed journal and will be submitted to relevant conferences.
摘要：
婴儿绞痛是一种常见的功能性胃肠病，在婴儿出生后的头几个月会影响婴儿。这种情况的病因尚不清楚。然而,一些研究表明，乳糖酶缺乏可能是一个促成因素。目前,关于饮食治疗和乳糖酶补充治疗婴儿绞痛的证据有限.我们旨在系统地审查使用乳糖酶补充剂治疗婴儿绞痛的有效性和安全性的证据。Cochrane中央对照试验登记册(中央，Cochrane图书馆)，MEDLINE,和EMBASE将被搜索，以确定使用任何公认的定义，比较口服乳糖酶补充剂与安慰剂或无干预对6个月以下婴儿的婴儿绞痛的随机对照试验。偏差风险将使用CochraneCollaboration的偏差风险工具的第二版进行评估。主要结果将是治疗后每组的反应者数量，定义为研究作者报告的每日哭闹减少的婴儿.其他结果将包括哭泣发作的持续时间和频率，婴儿睡眠持续时间，父母满意,婴儿的不适，住院人数，家庭生活质量,干预期间的不良事件。研究结果将发表在同行评审的期刊上，并提交给相关会议。
