PDF(Pubmed)
Abstract：
Modeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis for orthodontic treatment. Although previous reviews have indicated the significance of microRNAs (miRNAs) in bone metabolism, their roles in orchestrating maxillofacial bone modeling and remodeling remain unclear. This review aims to discuss the mechanisms by which miRNAs regulate the morphogenesis and development of maxillofacial bones, as well as their implications for maxillofacial malformations and malocclusion. Moreover, miRNAs participating in maxillofacial bone remodeling and their impacts on cell mechanosensing are also summarized. Given the intricate interplay of cells and signaling pathways, exosomal miRNAs emerge as the orchestrators of the modeling and remodeling processes. The diagnostic and therapeutic potentials of miRNAs are also highlighted in this review for future clinical applications.
摘要：
建模和重塑是颌面部骨骼发育和细化的重要过程。发育阶段的骨骼建模失调可能导致颌面部骨畸形和咬合不正。机械载荷下的骨重建是正畸治疗的生物学基础。尽管以前的综述已经指出了microRNAs（miRNAs）在骨代谢中的意义，它们在协调颌面骨建模和重建中的作用尚不清楚。本文旨在探讨miRNAs调控颌面部骨形态发生和发育的机制。以及它们对颌面部畸形和错牙合的影响。此外，还总结了参与颌面部骨重建的miRNA及其对细胞机械传感的影响。鉴于细胞和信号通路的复杂相互作用，外泌体miRNA作为建模和重塑过程的协调器出现。在这篇综述中还强调了miRNA的诊断和治疗潜力，用于未来的临床应用。
