PDF(Pubmed)
Abstract：
UNASSIGNED: Fetal growth restriction (FGR) is a common pregnancy complication, caused by placental insufficiency, with serious adverse consequences for development in utero and postnatal wellbeing. There are no antenatal treatments to improve growth or organ development in FGR, and animal models are essential to mimic the physiological adaptations in FGR and to assess potential interventions. This study aimed to identify the temporal nature of reduced developmental trajectory in fetuses with FGR, and to examine the effects of common factors that may mediate differential growth such as glucocorticoid treatment. We hypothesised that the trajectory of growth would be adversely impacted by FGR.
UNASSIGNED: FGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153).
UNASSIGNED: Body weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 days of gestation (term is 148 days), with increased brain:body weight ratio (p<0.0001) indicative of brain sparing. All biometric measures of body size were reduced in the FGR group with the exception of biparietal (head) diameter. The trajectory of body growth in the last trimester of sheep pregnancy was significantly reduced in the FGR group compared to controls, and stillbirth rate increased with longer gestation.
UNASSIGNED: This work provides a well characterised FGR animal model that mimics the known physiological adaptations in human pregnancy and can be used to determine the efficacy of potential interventions.
UNASSIGNED: FGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153).
UNASSIGNED: Body weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 days of gestation (term is 148 days), with increased brain:body weight ratio (p<0.0001) indicative of brain sparing. All biometric measures of body size were reduced in the FGR group with the exception of biparietal (head) diameter. The trajectory of body growth in the last trimester of sheep pregnancy was significantly reduced in the FGR group compared to controls, and stillbirth rate increased with longer gestation.
UNASSIGNED: This work provides a well characterised FGR animal model that mimics the known physiological adaptations in human pregnancy and can be used to determine the efficacy of potential interventions.
摘要：
胎儿生长受限（FGR）是一种常见的妊娠并发症，由胎盘功能不全引起的，对子宫内发育和产后健康有严重的不良后果。没有产前治疗来改善FGR的生长或器官发育，和动物模型对于模拟FGR的生理适应和评估潜在的干预措施至关重要。本研究旨在确定FGR胎儿发育轨迹减少的时间性质，并检查可能介导差异生长的常见因素的影响，如糖皮质激素治疗。我们假设增长轨迹会受到FGR的不利影响。
■FGR是通过胎羊（妊娠89天/妊娠0.6天；n=135）的手术胎盘功能不全诱发的，并与妊娠最后三分之一和新生儿生活中的年龄匹配的对照组进行比较（n=153）。
■从妊娠127天（足月148天）开始，FGR胎儿/羔羊的体重与对照组相比显着降低（p<0.0001），增加的脑:体重比(p<0.0001)指示脑保留。除了双顶（头）直径外，FGR组的所有生物特征测量均减少了。与对照组相比，FGR组在绵羊妊娠最后三个月的身体生长轨迹显着降低，死胎率随妊娠时间延长而增加。
■这项工作提供了一种特征良好的FGR动物模型，该模型模拟了人类怀孕中已知的生理适应，可用于确定潜在干预措施的功效。
■FGR是通过胎羊（妊娠89天/妊娠0.6天；n=135）的手术胎盘功能不全诱发的，并与妊娠最后三分之一和新生儿生活中的年龄匹配的对照组进行比较（n=153）。
■从妊娠127天（足月148天）开始，FGR胎儿/羔羊的体重与对照组相比显着降低（p<0.0001），增加的脑:体重比(p<0.0001)指示脑保留。除了双顶（头）直径外，FGR组的所有生物特征测量均减少了。与对照组相比，FGR组在绵羊妊娠最后三个月的身体生长轨迹显着降低，死胎率随妊娠时间延长而增加。
■这项工作提供了一种特征良好的FGR动物模型，该模型模拟了人类怀孕中已知的生理适应，可用于确定潜在干预措施的功效。
