UNASSIGNED: FGR was induced via surgical placental insufficiency in fetal sheep (89 days gestation/0.6 gestation; n=135) and compared to age-matched controls over the last third of gestation and into neonatal life (n=153).
UNASSIGNED: Body weight of FGR fetuses/lambs was significantly reduced compared to controls (p<0.0001) from 127 days of gestation (term is 148 days), with increased brain:body weight ratio (p<0.0001) indicative of brain sparing. All biometric measures of body size were reduced in the FGR group with the exception of biparietal (head) diameter. The trajectory of body growth in the last trimester of sheep pregnancy was significantly reduced in the FGR group compared to controls, and stillbirth rate increased with longer gestation.
UNASSIGNED: This work provides a well characterised FGR animal model that mimics the known physiological adaptations in human pregnancy and can be used to determine the efficacy of potential interventions.
■FGR是通过胎羊(妊娠89天/妊娠0.6天;n=135)的手术胎盘功能不全诱发的,并与妊娠最后三分之一和新生儿生活中的年龄匹配的对照组进行比较(n=153)。
■从妊娠127天(足月148天)开始,FGR胎儿/羔羊的体重与对照组相比显着降低(p<0.0001),增加的脑:体重比(p<0.0001)指示脑保留。除了双顶(头)直径外,FGR组的所有生物特征测量均减少了。与对照组相比,FGR组在绵羊妊娠最后三个月的身体生长轨迹显着降低,死胎率随妊娠时间延长而增加。
■这项工作提供了一种特征良好的FGR动物模型,该模型模拟了人类怀孕中已知的生理适应,可用于确定潜在干预措施的功效。