PDF(Pubmed)
Abstract：
Acute acalculous cholecystitis (AAC) represents cholecystitis without gallstones, occurring in approximately 5-10% of all cases of acute cholecystitis in adults. Several risk factors have been recognized, while infectious diseases can be a cause of cholecystitis in otherwise healthy people. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has spread worldwide, leading to an unprecedented pandemic. The virus enters cells through the binding of the spike protein to angiotensin-converting enzyme 2 (ACE2) receptors expressed in many human tissues, including the epithelial cells of the gastrointestinal (GI) tract, and this explains the symptoms emanating from the digestive system. Acute cholecystitis has been reported in patients with COVID-19. The purpose of this review is to provide a detailed analysis of the current literature on the pathogenesis, diagnosis, management, and outcomes of AAC in patients with COVID-19.
摘要：
急性非结石性胆囊炎（AAC）代表无胆结石的胆囊炎，约5-10％的成人急性胆囊炎病例。已经认识到几个危险因素，而传染病可能是其他健康人群胆囊炎的原因。2019年冠状病毒病（COVID-19）由严重急性呼吸道综合症冠状病毒2（SARS-CoV-2）引起，并已在全球范围内传播，导致前所未有的大流行。病毒通过刺突蛋白与许多人体组织中表达的血管紧张素转换酶2（ACE2）受体结合进入细胞，包括胃肠道（GI）的上皮细胞，这解释了消化系统的症状。据报道，COVID-19患者出现急性胆囊炎。这篇综述的目的是对目前关于发病机制的文献进行详细分析，诊断,管理,以及COVID-19患者的AAC结果。
