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Abstract：
BACKGROUND: Venous leg ulcers (VLUs) are a common chronic wound condition susceptible to infection by various bacterial species. Understanding bacterial presence and antibiotic sensitivity is crucial for effective treatment. Methodsː Medical records of 60 patients diagnosed with the C6 chronic venous insufficiency stage were analyzed retrospectively. The patients were divided into an active recurrent VLU group (33 cases) and a first-onset active VLU group (27 cases). Bacterial identification, antibiotic sensitivity, and laboratory markers were assessed. Resultsː Pseudomonas aeruginosa was the most prevalent bacterial species in both the study (72.72%) and control (37.03%) groups, along with other common bacteria such as Proteus mirabilis, Enterococcus sp., Staphylococcus aureus, Acinetobacter baumannii, Klebsiella spp., and Escherichia coli. Furthermore, uncommon bacteria, including Providencia rettgeri, Group B Streptococcus, and Salmonella Paratyphi B, and a fungal infection with Candida albicans, were identified only in the study group, while Morganella morganii was found exclusively in the control group. Pseudomonas aeruginosa showed significant sensitivity to several antibiotics, particularly Amikacin and Meropenem. Nonspecific laboratory markers, such as CRP, fibrinogen, ESR, WBC, CK, neutrophils, and lymphocytes, revealed statistically significant differences between groups, indicating their potential as biomarkers for monitoring recurrent VLUs. Conclusionsː These results highlight the need for comprehensive diagnostic approaches to effectively manage VLU infections and improve patient outcomes. Further research is warranted to explore factors influencing the presence of uncommon bacteria and to develop targeted interventions for VLU management.
摘要：
背景:静脉腿部溃疡(VLU)是一种常见的易受各种细菌种类感染的慢性伤口病症。了解细菌的存在和抗生素的敏感性对于有效治疗至关重要。方法回顾性分析60例C6慢性静脉功能不全患者的病历资料。将患者分为活动性复发VLU组(33例)和首发活动性VLU组(27例)。细菌鉴定,抗生素敏感性,和实验室标志物进行了评估。结果铜绿假单胞菌是研究组(72.72%)和对照组(37.03%)中最普遍的细菌种类，以及其他常见细菌，如奇异变形杆菌，肠球菌。,金黄色葡萄球菌,鲍曼不动杆菌,克雷伯菌属。,和大肠杆菌。此外，不常见的细菌，包括普罗维登西亚·雷特格里，B组链球菌,和乙型副伤寒沙门氏菌,和白色念珠菌的真菌感染，只在研究组中发现，而Morganellamorganii仅在对照组中发现。铜绿假单胞菌对几种抗生素有显著的敏感性,特别是阿米卡星和美罗培南。非特异性实验室标志物，如CRP，纤维蛋白原，ESR,WBC,CK,中性粒细胞，和淋巴细胞，揭示了组间的统计学差异，表明它们作为监测复发性VLU的生物标志物的潜力。这些结果强调了需要全面的诊断方法来有效管理VLU感染并改善患者预后。需要进一步的研究来探索影响罕见细菌存在的因素，并为VLU管理制定有针对性的干预措施。
