PDF(Pubmed)
Abstract：
The microbiota in the oral cavity has a strict connection to its host. Its imbalance may determine oral diseases and can also have an impact on the systemic health. Probiotic strains may help in the restoration of a balanced condition. For this purpose, we screened the antibacterial and antiadhesive activities of many viable probiotic strains (Lactobacillus acidophilus PBS066, Lactobacillus crispatus LCR030, Lactobacillus gasseri LG050, Lactiplantibacillus plantarum PBS067, Limosilactobacillus reuteri PBS072, Lacticaseibacillus rhamnosus LRH020, Bifidobacterium animalis subsp. lactis BL050, Lacticaseibacillus paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114) against two main oral pathogens, Streptococcus mutans and Aggregatibacter actinomycetemcomitans, involved in dental caries and periodontal disease development and progression. Considering both the agar overlay preventive and treatment models, seven probiotics determined greater inhibition zones against the tested pathogens. This behavior was further analyzed by the plate count method and scanning electron microscope imaging. L. plantarum PBS067, L. rhamnosus LRH020, L. paracasei LPC 1101, L. paracasei LPC 1082, and L. paracasei LPC 1114 prevent the growth and adhesion of oral pathogens in a strain-specific manner (p < 0.0001). These probiotics might be considered as an alternative effective adjuvant to improve oral and systemic well-being for future personalized treatments.
摘要：
口腔中的微生物群与其宿主有严格的联系。它的不平衡可能决定口腔疾病，也可能对全身健康产生影响。益生菌菌株可能有助于恢复平衡状态。为此,我们筛选了许多有活力的益生菌菌株（嗜酸乳杆菌PBS066，卷曲乳杆菌LCR030，加氏乳杆菌LG050，植物乳杆菌PBS067，罗氏林杆菌PBS072，羊乳杆菌LRH020。乳酸BL050，副干酪乳杆菌LPC1101，副干酪乳杆菌LPC1082和副干酪乳杆菌LPC1114）针对两种主要的口腔病原体，变形链球菌和放线菌，参与龋齿和牙周病的发展和进展。考虑到琼脂覆盖预防和治疗模型，七种益生菌确定了对测试病原体的更大抑制区。通过平板计数法和扫描电子显微镜成像进一步分析了这种行为。植物乳杆菌PBS067，鼠李糖乳杆菌LRH020，副干酪乳杆菌LPC1101，副干酪乳杆菌LPC1082和副干酪乳杆菌LPC1114以菌株特异性方式防止口腔病原体的生长和粘附（p<0.0001）。这些益生菌可能被认为是改善口腔和全身健康的替代有效佐剂，用于未来的个性化治疗。
