PDF(Pubmed)
Abstract：
Chronic exposure to potentially toxic elements (PTEs) such as cadmium (Cd) leads to male reproductive toxicity through the generation of oxidative stress. Spirulina Arthrospira maxima (AM) is a cyanobacterium that has been consumed since ancient times for its high nutritional value, and in recent years for its antiviral, hepatoprotective, hypoglycemic, anticancer, and antioxidant effects, among others. This study aimed to evaluate the effects of AM against the damage to reproductive health induced by Cd. A total of 48 10-week-old sexually experienced male Wistar rats were distributed in five groups (n = 8): control; vehicle (tween-water); cadmium chloride (CdCl2) 5 mg/kg; and three doses of AM (100, 200 and 400 mg/kg) + CdCl2 5 mg/kg. All treatments were orally administered once a day for 36 consecutive days. At the end, sexual behavior was evaluated, and semen, testicle, and blood samples were obtained to analyze sperm quality, enzymatic activity, and testosterone levels, respectively. Rats exposed to Cd showed a decrease in sexual behavior, as well as in the quality of reproductive health, and an increase in oxidative stress; while rats exposed simultaneously to AM + Cd showed an improvement in all this parameters. Based on our results, we believe that the mechanism by which AM exerts its effect could be attributed to the presence of phycobiliproteins. These compounds are responsible for exerting an antioxidant effect and chelating effect on elements such as Cd.
摘要：
长期暴露于镉（Cd）等潜在毒性元素（PTE）会通过产生氧化应激导致男性生殖毒性。螺旋藻最大节旋藻（AM）是一种蓝细菌，自古以来就因其高营养价值而被食用，近年来，由于它的抗病毒作用，保肝,低血糖,抗癌，和抗氧化作用，在其他人中。本研究旨在评价AM对Cd致生殖健康损害的影响。共有48只10周龄有性经历的雄性Wistar大鼠分为五组（n=8）：对照组；媒介物（吐温水）；氯化镉（CdCl2）5mg/kg；和三种剂量的AM（100、200和400mg/kg）CdCl25mg/kg。所有治疗均口服给药,每天一次,连续36天。最后,对性行为进行了评估，还有精液,睾丸,获得血液样本来分析精子质量，酶活性，和睾丸激素水平，分别。暴露于Cd的大鼠表现出性行为的减少，以及生殖健康的质量，和氧化应激的增加；而同时暴露于AMCd的大鼠显示出所有这些参数的改善。根据我们的结果,我们认为，AM发挥其作用的机制可能归因于藻胆蛋白的存在。这些化合物负责对元素如Cd发挥抗氧化作用和螯合作用。
