PDF(Pubmed)
Abstract：
Coordination cages sustained by metal-ligand interactions feature polyhedral architectures and well-defined hollow structures, which have attracted significant attention in recent years due to a variety of structure-guided promising applications. Sulfonylcalix[4]arenes-based coordination cages, termed metal-organic supercontainers (MOSCs), that possess unique multi-pore architectures containing an endo cavity and multiple exo cavities, are emerging as a new family of coordination cages. The well-defined built-in multiple binding domains of MOSCs allow the efficient encapsulation of guest molecules, especially for drug delivery. Here, we critically discuss the design strategy, and, most importantly, the recent advances in research surrounding cavity-specified host-guest chemistry and biomedical applications of MOSCs.
摘要：
由金属-配体相互作用维持的配位笼具有多面体结构和定义明确的中空结构，近年来，由于各种结构引导的应用前景广阔，引起了人们的广泛关注。磺酰杯[4]芳烃基配位笼，称为金属有机超级容器(MOSCs)，具有独特的多孔结构，包含一个内腔和多个外腔，正在成为一个新的协调笼家族。明确定义的MOSCs的内置多结合域允许客体分子的有效封装，尤其是给药。这里,我们批判性地讨论设计策略，and,最重要的是,围绕腔指定的宿主-客体化学和MOSCs生物医学应用的研究进展。
