PDF(Pubmed)
Abstract：
Endometrial cancer (EC) is the most common gynecological malignancy. This study aimed to evaluate the expression of E-cadherin and N-cadherin in primary endometrial lesions and the endocervix in patients with EC to identify noninvasive predictive factors. In this single-center retrospective study, data on 101 patients who underwent surgery for EC were collected. The immunohistochemical expression of E-cadherin and N-cadherin was assessed depending on the tumor grade, location, and cell differentiation. Correlations between E-cadherin and N-cadherin levels in the endocervix and the primary tumor were determined. The degree of histological tumor differentiation significantly affected E-cadherin expression (p = 0.04) but had no impact on N-cadherin levels. In type II EC, the expression of both cadherins in the tumor tissue differed from their endocervical levels. The expression of E-cadherin differed significantly between the endocervix (p < 0.001) and the tumor (p = 0.001), depending on the type of EC. The expression of E-cadherin was related to the N-cadherin level only in the endocervix in patients with type II EC (p = 0.02). E-cadherin and N-cadherin were expressed in the endocervix in patients with EC. The expression of cadherins, determined during cervical cytology, may be a valuable clinical marker of EC.
摘要：
子宫内膜癌是最常见的妇科恶性肿瘤。本研究旨在评估E-cadherin和N-cadherin在原发性子宫内膜病变和宫颈内膜中的表达，以确定非侵入性预测因素。在这项单中心回顾性研究中,收集了101例接受EC手术的患者的数据.根据肿瘤分级评估E-cadherin和N-cadherin的免疫组织化学表达，location,和细胞分化。确定了宫颈内膜和原发性肿瘤中E-钙粘蛋白和N-钙粘蛋白水平之间的相关性。组织学肿瘤分化程度显着影响E-cadherin表达（p=0.04），但对N-cadherin水平没有影响。在II型EC中，两种钙黏着蛋白在肿瘤组织中的表达与其宫颈内膜水平不同。E-cadherin的表达在宫颈内膜（p<0.001）和肿瘤（p=0.001）之间存在显着差异，取决于EC的类型。E-cadherin的表达仅与II型EC患者宫颈内膜中的N-cadherin水平相关（p=0.02）。E-cadherin和N-cadherin在EC患者宫颈内膜中表达。钙黏着蛋白的表达，在宫颈细胞学检查中确定，可能是EC的一个有价值的临床标志物。
