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Abstract：
Breast cancer is the second leading contributor to the age-standardized mortality rate, for both sexes and all ages worldwide. In Europe and the United States, it is the second leading cause of mortality, with an incidence rate of about 2.6 million cases per year. Noscapine, a well-known alkaloid used as a cough suppressant, demonstrated anti-tumor effects by triggering apoptosis in various cancer cell lines and has the potential to become another ally against breast, ovarian, colon, and gastric cancer, among other types of malignancy. Apoptosis plays a crucial role in the treatment of cancer. Noscapine affected BAX, CASP8, CASP9, NFKBIA, and RELA gene and protein expression in the MCF-7 and MDA-MB-231 cell lines. Gene expression was higher in tumor than in normal tissue, including the BAX expression levels in lung, ovary, endometrium, colon, stomach, and glioblastoma patients; BCL2L1 expression in endometrium, colon, and stomach patients; CASP8 gene expression levels in lung, endometrium, colon, stomach, and glioblastoma patients; RELA in colon, stomach, and glioblastoma patients; and NFKBIA in glioblastoma patients. It can be concluded that noscapine affected genes and proteins related to apoptosis in cancer cell lines and several types of cancer patients.
摘要：
乳腺癌是年龄标准化死亡率的第二大贡献者，适用于全球男女和所有年龄段。在欧洲和美国,它是第二大死亡原因，每年的发病率约为260万例。Noccapine,一种众所周知的生物碱，用作止咳药，通过在各种癌细胞系中触发细胞凋亡来证明抗肿瘤作用，并有可能成为另一个对抗乳腺癌的盟友，卵巢,结肠,和胃癌，在其他类型的恶性肿瘤中。细胞凋亡在肿瘤的治疗中起着至关重要的作用。Noccapine受影响BAX，CASP8,CASP9,NFKBIA,MCF-7和MDA-MB-231细胞系中RELA基因和蛋白质的表达。肿瘤中的基因表达高于正常组织，包括BAX在肺中的表达水平，子房,子宫内膜,结肠,胃,和胶质母细胞瘤患者；子宫内膜中BCL2L1的表达，结肠,和胃患者；肺CASP8基因表达水平，子宫内膜,结肠,胃,和胶质母细胞瘤患者；结肠RELA，胃,和胶质母细胞瘤患者；胶质母细胞瘤患者的NFKBIA。可以得出结论，在癌细胞系和几种类型的癌症患者中，noscapine会影响与凋亡相关的基因和蛋白。
