Abstract:
Xanthohumol (Xn), a prenylated chalcone found in Hop (Humulus lupulus L.), has been shown to have potent anti-aging, diabetes, inflammation, microbial infection, and cancer properties. Unfortunately, this molecule has undesirable characteristics such as inadequate intake, low aqueous solubility, and a short half-life. To address these drawbacks, researchers have made numerous attempts to improve its absorption, solubility, and bioavailability. Polymeric drug delivery systems (PDDSs) have experienced significant development over the last two decades. Polymeric drug delivery is defined as a formulation or device that allows the introduction of a therapeutic substance into the body. Biodegradable and bioreducible polymers are the ideal choice for a variety of new DDSs. Xn formulations based on biodegradable polymers and naturally derived compounds could solve some of the major drawbacks of Xn-based drug delivery. In this regard, the primary concern of this study is on presenting innovative formulations for Xn delivery, such as nanoparticles (NPs), nanomicelles, nanoliposomes, solid lipid nanoparticles (SLNs), and others, as well as the received in vitro and in vivo data. Furthermore, this work describes the chemistry and broad biological activity of Xn, which is particularly useful in modern drug technology as well as the cosmetics industry. It is also important to point out that the safety of using Xn, and its biotransformation, pharmacokinetics, and clinical applications, have been thoroughly explained in this review.
摘要:
黄腐酚(Xn),在Hop(HumuluslupulusL.)中发现的异戊二烯化查尔酮,已经被证明具有有效的抗衰老作用,糖尿病,炎症,微生物感染,和癌症属性。不幸的是,这种分子具有不良特征,如摄入不足,低水溶性,半衰期短。为了解决这些缺点,研究人员进行了许多尝试来改善其吸收,溶解度,和生物利用度。在过去的二十年中,聚合物药物递送系统(PDDS)经历了显著的发展。聚合物药物递送被定义为允许将治疗物质引入体内的制剂或装置。可生物降解和可生物还原的聚合物是各种新型DDS的理想选择。基于生物可降解聚合物和天然衍生化合物的Xn制剂可以解决基于Xn的药物递送的一些主要缺点。在这方面,这项研究的主要关注点是为XN交付提供创新的配方,如纳米粒子(NPs),纳米胶束,纳米脂质体,固体脂质纳米粒(SLN),和其他人,以及收到的体外和体内数据。此外,这项工作描述了Xn的化学和广泛的生物活性,这在现代药物技术以及化妆品行业中特别有用。同样重要的是要指出使用Xn的安全性,和它的生物转化,药代动力学,和临床应用,在这次审查中已经得到了彻底的解释。