基于 BMP2 - ERK - ATF4 轴的 6 - 甲氧基苯并呋喃化合物 I - 9 作为骨形成和抗骨质疏松的候选药物。
关键词: 6-methoxybenzofuran ATF4 BMP-2 bone formation osteoblast osteoporosis
Mesh : Aged Mice Humans Animals Osteogenesis Pharmaceutical Preparations / metabolism Osteoporosis / drug therapy metabolism Bone Density Conservation Agents / therapeutic use Peptides / metabolism Cell Differentiation Osteoblasts / metabolism Activating Transcription Factor 4 / metabolism Bone Morphogenetic Protein 2 / metabolism
来 源:
DOI:10.3390/ijms25063350
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