PDF(Pubmed)
Abstract：
Mitochondria are eukaryotic cellular organelles that function in energy metabolism, ROS production, and programmed cell death. Cutaneous epithelial and hair follicle dermal papilla cells are energy-rich cells that thereby may be affected by mitochondrial dysfunction and DNA mutation accumulation. In this review, we aimed to summarize the medical literature assessing dermatologic conditions and outcomes associated with mitochondrial dysfunction. A search of PubMed and Embase was performed with subsequent handsearching to retrieve additional relevant articles. Mitochondrial DNA (mtDNA) deletions, mutation accumulation, and damage are associated with phenotypic signs of cutaneous aging, hair loss, and impaired wound healing. In addition, several dermatologic conditions are associated with aberrant mitochondrial activity, such as systemic lupus erythematosus, psoriasis, vitiligo, and atopic dermatitis. Mouse model studies have better established causality between mitochondrial damage and dermatologic outcomes, with some depicting reversibility upon restoration of mitochondrial function. Mitochondrial function mediates a variety of dermatologic conditions, and mitochondrial components may be a promising target for therapeutic strategies.
摘要：
线粒体是在能量代谢中起作用的真核细胞细胞器，ROS生产，和程序性细胞死亡。皮肤上皮和毛囊毛乳头细胞是能量丰富的细胞，因此可能受到线粒体功能障碍和DNA突变积累的影响。在这次审查中,我们旨在总结评估与线粒体功能障碍相关的皮肤病和结局的医学文献.对PubMed和Embase进行搜索，随后进行手工搜索以检索其他相关文章。线粒体DNA(mtDNA)缺失,突变积累，损伤与皮肤老化的表型迹象有关，脱发,伤口愈合受损。此外,几种皮肤病与线粒体活性异常有关，比如系统性红斑狼疮,牛皮癣,白癜风,和特应性皮炎。小鼠模型研究在线粒体损伤和皮肤病学结果之间建立了更好的因果关系，其中一些描绘了线粒体功能恢复后的可逆性。线粒体功能介导各种皮肤病，和线粒体成分可能是治疗策略的有希望的靶标。
