PDF(Pubmed)
Abstract：
The long-term effects of environmental pollution have been of concern as several pollutants are carcinogenic, potentially inducing a variety of cancers, including childhood cancer, which is a leading cause of death around the world and, thus, is a public health issue. The present scoping review aimed to update and summarize the available literature to detect specific environmental pollutants and their association with certain types of childhood cancer. Studies published from 2013 to 2023 regarding environmental pollution and childhood cancer were retrieved from the PubMed database. A total of 174 studies were eligible for this review and were analyzed. Our search strategy brought up most of the articles that evaluated air pollution (29%) and pesticides (28%). Indoor exposure to chemicals (11%), alcohol and tobacco use during pregnancy (16%), electromagnetic fields (12%), and radon (4%) were the subjects of less research. We found a particularly high percentage of positive associations between prenatal and postnatal exposure to indoor (84%) and outdoor (79%) air pollution, as well as to pesticides (82%), and childhood cancer. Positive associations were found between leukemia and pesticides and air pollution (33% and 27%); CNS tumors and neuroblastoma and pesticides (53% and 43%); and Wilms tumor and other rare cancers were found in association with air pollution (50%). Indoor air pollution was mostly reported in studies assessing several types of cancer (26%). Further studies are needed to investigate the mechanisms underlying the potential associations between indoor/outdoor air pollution and pesticide exposure with childhood cancer risk as more preventable measures could be taken.
摘要：
环境污染的长期影响一直受到关注，因为几种污染物具有致癌性，可能诱发多种癌症，包括儿童癌症，这是世界各地死亡的主要原因，因此，是一个公共卫生问题。本范围审查旨在更新和总结现有文献，以检测特定的环境污染物及其与某些类型的儿童癌症的关联。从PubMed数据库检索了2013年至2023年发表的有关环境污染和儿童癌症的研究。共有174项研究符合本综述的条件并进行了分析。我们的搜索策略带来了大多数评估空气污染（29％）和农药（28％）的文章。室内接触化学品(11%)，怀孕期间饮酒和吸烟（16％），电磁场（12%），氡(4%)的研究对象较少。我们发现产前和产后暴露于室内（84％）和室外（79％）空气污染之间的正相关比例特别高。以及杀虫剂（82%），儿童癌症。发现白血病与杀虫剂和空气污染之间存在正相关（33％和27％）;中枢神经系统肿瘤和神经母细胞瘤和杀虫剂（53％和43％）;发现Wilms肿瘤和其他罕见癌症与空气污染有关（50％）。室内空气污染主要在评估几种癌症的研究中报道（26％）。需要进一步的研究来调查室内/室外空气污染和农药暴露与儿童癌症风险之间潜在关联的机制，因为可以采取更多的预防措施。
