PDF(Pubmed)
Abstract：
This review focuses on non-surgical treatment options for rotator cuff injuries and highlights the potential of mesenchymal stem cells (MSCs) as a potential regenerative approach. MSCs, sourced from various tissues like bone marrow and adipose tissue, exhibit promising mechanisms in vitro, influencing tendon-related gene expression and microenvironment modulation. Animal studies support this, showcasing MSCs\' ability to reduce inflammation, improve tissue remodeling, and enhance repaired tendon strength. Human trials, while varied and limited, suggest that MSCs might lower retear rates and enhance post-repair outcomes, but randomized controlled trials yield mixed results, emphasizing the necessity for standardized investigations. Ultimately, while cell-based therapies demonstrate an excellent safety profile, more rigorous clinical trials are necessary to determine their efficacy in improving patient outcomes and achieving lasting structural changes in rotator cuff injuries.
摘要：
这篇综述重点介绍了肩袖损伤的非手术治疗方案，并强调了间充质干细胞（MSCs）作为一种潜在的再生方法的潜力。MSCs,来自骨髓和脂肪组织等各种组织，在体外表现出有希望的机制，影响肌腱相关基因表达和微环境调节。动物研究支持这一点，展示MSCs减少炎症的能力，改善组织重塑，增强修复后的肌腱强度。人体试验,虽然变化和有限，提示MSCs可能降低再撕裂率并增强修复后结果，但是随机对照试验结果好坏参半，强调标准化调查的必要性。最终,虽然基于细胞的疗法显示出优异的安全性，需要更严格的临床试验来确定其在改善患者预后和实现肩袖损伤的持久结构改变方面的功效.
