PDF(Pubmed)
Abstract：
One of the common illnesses that affect women\'s physical and mental health is urinary tract infection (UTI). The disappointing results of empirical anti-infective treatment and the lengthy time required for urine bacterial culture are two issues. Antibiotic misuse is common, especially in females who experience recurrent UTI (rUTI). This leads to a higher prevalence of antibiotic resistance in the microorganisms that cause the infection. Antibiotic therapy will face major challenges in the future, prompting clinicians to update their practices. New testing techniques are making the potential association between the urogenital microbiota and UTIs increasingly apparent. Monitoring changes in female urinary tract (UT) microbiota, as well as metabolites, may be useful in exploring newer preventive treatments for UTIs. This review focuses on advances in urogenital microbiology and organismal metabolites relevant to the identification and handling of UTIs in an attempt to provide novel methods for the identification and management of infections of the UT. Particular attention is paid to the microbiota and metabolites in the patient\'s urine in relation to their role in supporting host health.
摘要：
尿路感染是影响女性身心健康的常见疾病之一。经验性抗感染治疗的令人失望的结果和尿液细菌培养所需的长时间是两个问题。滥用抗生素很常见，尤其是在经历复发性UTI（rUTI）的女性中。这导致引起感染的微生物中抗生素抗性的更高流行率。未来抗生素治疗将面临重大挑战，促使临床医生更新他们的做法。新的检测技术使泌尿生殖系统微生物群和尿路感染之间的潜在关联日益明显。监测女性泌尿道（UT）微生物群的变化，以及代谢物，可能有助于探索尿路感染的新的预防性治疗。这篇综述的重点是与UTI的鉴定和处理相关的泌尿生殖微生物学和有机代谢物的进展，以期为UT感染的鉴定和管理提供新的方法。特别注意患者尿液中的微生物群和代谢产物在支持宿主健康中的作用。
