PDF(Pubmed)
Abstract：
Background: While obesity has been shown to elevate the risk of developing multiple sclerosis (MS), there is a lack of strong evidence regarding its role in the disability progression and status of MS patients. Methods: This systematic review and meta-analysis aimed to provide comparative estimates of WC and BMI in patients with MS (PwMS) and to investigate potential associations between the waist circumference (WC) and body mass index (BMI) and demographic and specific MS characteristics. Adhering to PRISMA guidelines, a detailed search of the MEDLINE PubMed, Cochrane Library, and Scopus databases was conducted. Results: A total of 16 studies were included. The pooled mean WC and BMI among PwMS was estimated to be 87.27 cm (95%CI [84.07; 90.47]) and 25.73 (95%CI [25.15; 26.31]), respectively. Meta-regression models established a significant bidirectional relationship between WC and the Expanded Disability Scale (EDSS) (p < 0.001) but not between BMI and EDSS (p = 0.45). Sensitivity analyses showed no association between WC and age (p = 0.48) and a tendency between WC and disease duration (p = 0.08). Conclusions: Although WC measurements classify PwMS as normal weight, BMI measurements classify them as overweight. Therefore, WC should complement BMI evaluations in clinical practice. Additionally, our findings highlight the significant association between abdominal fat, as indicated by WC, and disease progression. Considering the heightened risk of cardiovascular comorbidity and mortality among PwMS, we recommend integrating both WC and BMI as standard anthropometric measurements in routine clinical examinations and targeted prevention strategies for PwMS.
摘要：
背景：虽然肥胖已被证明会增加患多发性硬化症（MS）的风险，缺乏关于其在MS患者残疾进展和状况中的作用的有力证据.方法：本系统综述和荟萃分析旨在提供MS（PwMS）患者WC和BMI的比较估计，并研究腰围（WC）和体重指数（BMI）与人口统计学和特定MS特征之间的潜在关联。坚持PRISMA准则，MEDLINEPubMed的详细搜索，科克伦图书馆,并进行了Scopus数据库。结果：共纳入16项研究。PwMS的总平均WC和BMI估计为87.27cm（95CI[84.07;90.47]）和25.73（95CI[25.15;26.31]），分别。Meta回归模型在WC和扩展残疾量表（EDSS）之间建立了显着的双向关系（p<0.001），而在BMI和EDSS之间则没有（p=0.45）。敏感性分析显示WC与年龄之间没有关联（p=0.48），WC与疾病持续时间之间有趋势（p=0.08）。结论：尽管WC测量将PwMS分类为正常体重，BMI测量将它们归类为超重。因此,WC应补充临床实践中的BMI评估。此外,我们的发现强调了腹部脂肪之间的显著关联，如WC所示，和疾病进展。考虑到PwMS中心血管合并症和死亡率的风险增加，我们建议在常规临床检查和针对PwMS的针对性预防策略中,将WC和BMI作为标准人体测量值.
